This thesis obtained population-based insights into early phases of Parkinson's disease in order to guide future prevention and disease-modification trials

Dommershuijsen, Lisanne

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Propositions accompanying the thesis A Population Perspective on Parkinson’s Disease  1. Better recognition of prodromal symptoms of Parkinson’s disease inevitably provokes ethical dilemmas, which should be considered in research protocols. (this thesis)   2. Orthostatic hypotension should not be included in the Movement Disorder Society research criteria for prodromal Parkinson’s disease. (this thesis)  3. Tailored interventions are required to improve COVID-19 related depression and anxiety in people with Parkinson’s disease. (this thesis)  4. Diet quality is a promising target for upcoming Parkinson’s disease prevention trials. (this thesis)  5. The life expectancy of people with Parkinson’s disease is reduced compared to people without Parkinson’s disease, especially in younger individuals. (this thesis)  6. Our current concept of prodromal Parkinson’s disease is, in fact, Parkinson’s disease. (D. Berg and R. Postuma, Journal of Parkinson’s Disease, 2018)  7. Many previous trials were flawed by assuming that Parkinson’s disease can be defined as a single diagnostic entity, without taking into consideration the complexity, diversity and timing of pathogenesis. (Adapted from: P. Poortvliet, Frontiers in Neurology, 2020)   8. Replication studies should be conducted more frequently and systematically and this requires a joint effort from funding agencies, scientific journals, institutions and researchers. (J. van Dijck, KNAW, 2018)  9. Nothing in science has any value to society if it is not communicated. (A. Roe, The Making of a Scientist, 1952)  10. We have lived our lives by the assumption that what was good for us would be good for the world. We have been wrong. What is good for the world will be good for us. (Adapted from: W. Berry, The Long-Legged House, 1969)   11. Only by working together can we recover better and build a world where everyone thrives in peace, dignity, and equality on a healthy planet. (A. Mohammed, 2021)  

A Population Perspective on Parkinson’s Disease

https://pure.eur.nl/files/50346922/propositions_615d77f3c4a3b.pdf

A Population Perspective on Parkinson’s Disease

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