Background: The aims of this study are to estimate the
profile of bone loss biomarkers in peri-implant tissues and to
identify potential prognostic biomarkers of peri-implantitis.
Methods: Peri-implant crevicular fluid samples collected
from 164 participants (52 patients with peri-implantitis, 54
with mucositis, and 58 with healthy peri-implant tissues)
were analyzed using enzyme-linked immunosorbent assays
to evaluate concentrations of the receptor activator of nuclear factor-kB (RANK), soluble RANK ligand (sRANKL),
osteoprotegerin (OPG), cathepsin-K, and sclerostin.
Results: Concentrations of RANK, sRANKL, OPG, and
sclerostin were significantly increased in patients with periimplantitis compared with patients with healthy peri-implant
tissues. Comparisons between peri-implantitis and mucositis demonstrated significantly higher values of sclerostin in
peri-implantitis samples. Comparisons between mucositis and
healthy peri-implant tissues showed significantly increased
levels of RANK and cathepsin-K in mucositis.
Conclusion: These results are suggestive of a role of
sRANKL, OPG, and sclerostin as prognostic biomarkers in
peri-implantiti
