Budai, István

Szoboszlai, András

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      ACTA ACADEMIAE NYIREGYHAZIENSIS      M T SZAKKELET- M R 2022   Szerkesztette: P                 ISSN: 2416-2981 ISBN: 978-615-6032-57-7      t szakkelet-m rKONFERENCIA-           Dr. Kocsis Imre ,      Dr. P   A   Mi      :       9  10 : Material test, microstructure and size accuracy investigations on parts   11     17  Alexa Regina:    18 Beszeda Imre  :  ....... 24  : A l    30 :  Development of a test facility for modelling    36  Stock Bence:    42  Tarek Mohamed: A   50  Apagyi Vivien:  (Lupinus    56 Uri Zsuzsanna   Holb Imre: Az ..  62 Vigh Szabolcs: A  68    74 :  75 Boros Rafael Ruben  :  ..  81 Hancz Gabriella:    87   :   93 Matusz- :  -  99  :   105     .. 111 Baksa Attila     : Saint-Venant   112  :  118  Tiba Zsolt     :   Design and finite element analysis of planetary gear drives by the number of planet    126 Szigeti Ferenc    :   132  : -  138   . ...  145  Roland  : Multiple steel capillary model: A new method ...  146   :  -..   152   : A Bayes-    158   : Szabolcs- - -  164 -  Hompoth Szabolcs   : A - . .   170 :   176 Varga Gyula  : A CO2-  183   .  189  Bertalan Eszter Viola: . ....  190 Hajnal Andor     : A ..  196 138  -  Development of a polysaccharide-matrix capsule with a cellular structure for pharmaceutical use  1  2   1 4. 4225, andras.szoboszlai@neopac.com 2 4. 4225, budai.istvan@eng.unideb.hu   a   nek ,  alkalmaznak, amelyek anak , a pektin bizonyult  -ra -l uk.  Kulcsszavak:   Abstract: Nowadays, more and more companies are trying to reduce the use of artificial and animal-based ingredients in their production processes, and plant-based products are becoming more common. The pharmaceutical industry is not an exception. The most common oral dosage forms are hard and soft gelatine capsules. Gelatine is extracted from collagen of animal origin, which makes its use unpopular with certain lifestyles and religions. Our aim is to develop a pharmaceutical formulation with a cellular structure that is suitable to replace the gelatin capsules used in the current pharmaceutical industry. The cellular structure will facilitate better utilisation of the active ingredient and reduce the amount of carrier matrix. Our aim was to produce a stable floating formulation by foaming. Among the matrix gredient and then foamed with air at atmospheric pressure using an ultrasonic homogenizer. The structure of the formulated solid foam was investigated by microCT. Our experiments showed that a stable foam could be obtained by rapid homogenization without surfactant or any other additives. The durability and disintegration in the gastric environment of the solid foam capsules were investigated, as well as the release of the active ingredient.  Keywords: polysaccharide, pharmaceutical dosage form, cellular structure, solid foam capsule     - -s alapanyag-   139 -[8].  A  --hiper        - ek  [15] [16].      2.1. Anyagok   : metronidazol   2.2. A h    -[17].  2.3.   -nyi (24 g) metronidazol -- a kompozit el nem kezdett dermedni-le   140  2.4. -   - - -klorid-oldatot alkalmaztunk [18]. -- --   2.5. A n - a  t- - --  2.6.   -- -     3.1.   - --  kellett - jelen esetben a metronidazol   nkompozit -   141 . - e s   ben) lebegni.   2. bra.   3.2.   - ---     .  perc alatt --hogy a pektin habkapszula k -,   142     . A  kifejezve   3.3. A n - a   .   .  -  3.4. S   -  143 mutat, am- - -     . o -     , - A kifejleszteni   - -    z I -21-5  j Nemzeti K  P  a Nemzeti K , F   I  A   szakmai  dr. Haimhoffer , a Debreceni Egyetem  r. a Debreceni   a mikroCT-     [1]  D. Weaire, S. Hutzler, The Physics of Foams, Oxford, Oxford University Press, 2001, ISBN: 978-0198510970 [2]  -730, doi: 10.1016/j.crhy.2014.09.006 [3]  20, 2022.  [3]  Singh, A. B - Bioactive and drug-delivery potentials of 19 48, doi: 10.1016/B978-0-08-102553-6.00002-7. doi: 10.1016/j.nano.2015.02.018.  144 [4]  -Ther., 2019, pp: 529 543, doi: 10.1124/jpet.118.255828. [5]  ing the factors affecting drug absorption: A 643. doi: 10.1177/009700020420060058 [6]  sys  [7]  J.F. Reinus, S. 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Cellás szerkezetű, poliszacharid-mátrixú kapszula fejlesztése gyógyászati felhasználásra = Development of a polysaccharide-matrix capsule with a cellular structure for pharmaceutical use

http://real.mtak.hu/175050/1/ActaNyir2022.pdf

Cellás szerkezetű, poliszacharid-mátrixú kapszula fejlesztése gyógyászati felhasználásra = Development of a polysaccharide-matrix capsule with a cellular structure for pharmaceutical use

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