DNA origami is a method used to program the self-assembly of nanoscale computational systems. The contribution of this paper is to probe the security of a canonical DNA origami that is often reused. The paper describes the techniques we used to design probes whose input targets the origami systems’ integrity. Experimental results show that the probes successfully caused up to a third of the systems to fail. Moreover, our approach identified a single, small input whose addition was able to cause the failure of a quarter of the systems. Extending such probes to other DNA origami systems may aid in understanding how to enhance their reliability.This is a manuscript of a proceeding from C. Koehler, D. Mathur, E. Henderson and R. Lutz, "Probing the Security of DNA Origami," 2018 IEEE International Symposium on Software Reliability Engineering Workshops (ISSREW), Memphis, TN, 2018, pp. 138-139, doi: 10.1109/ISSREW.2018.00-14. Posted with permission.</p
