A method for the trifluoromethylation of arylsilanes is reported. The reaction proceeds with [(phen)CuCF3 ] as the CF3  source under mild, oxidative conditions with high functional-group compatibility. This transformation complements prior trifluoromethylation of arenes in several ways. Most important, this method converts arylsilanes formed by the silylation of aryl C-H bonds to trifluoromethylarenes, thereby allowing the conversion of arenes to trifluoromethylarenes. The unique capabilities of the reported method are demonstrated by the conversion of a C-H bond into a C-CF3 bond in active pharmaceutical ingredients which do not undergo this overall transformation by alternative functionalization processes, including a combination of borylation and trifluoromethylation

Cheng, Chen

Hartwig, John F

Hou, Haiyun

Morstein, Johannes

eScholarship - University of California

UC BerkeleyUC Berkeley Previously Published WorksTitleTrifluoromethylation of Arylsilanes with [(phen)CuCF3]Permalinkhttps://escholarship.org/uc/item/8p93j3dfJournalAngewandte Chemie International Edition, 55(28)ISSN1433-7851AuthorsMorstein, JohannesHou, HaiyunCheng, Chenet al.Publication Date2016-07-04DOI10.1002/anie.201601163 Peer reviewedeScholarship.org Powered by the California Digital LibraryUniversity of CaliforniaTrifluoromethylation of Arylsilanes with (phen)CuCF3Johannes Morstein†, Haiyun Hou†, Chen Cheng, and Prof. Dr. John F. Hartwig*Department of Chemistry, University of California, Berkeley Berkeley, CA 94720 (USA)AbstractA method for the trifluoromethylation of arylsilanes is reported. The reaction occurs with (phen)CuCF3 as the CF3-source under mild, oxidative conditions with high functional group compatibility. This transformation complements prior trifluoromethylation of arenes in several ways. Most important, this method converts arylsilanes formed by the silylation of aryl C-H bonds to trifluoromethylarenes, thereby allowing the conversion of arenes to trifluoromethylarenes. The unique capabilities of the reported method are demonstrated by the conversion of a C-H bond to a C-CF3 bond in active pharmaceutical ingredients that do not undergo this overall transformation by alternative functionalization processes, including a combination of borylation and trifluoromethylation.Graphical abstractKeywordsArylsilanes; Cross Coupling; C-Si Functionalization; Late Stage Functionalization; TrifluoromethylationFluoroalkyl substituents modulate physicochemical properties, metabolic stability, and protein-ligand interactions.[1] For this reason, approximately 30% of the most recently approved drugs contain fluorine, and nearly half of these fluorinated molecules contain a trifluoromethyl group.[2] Yet, most commercial syntheses of trifluoromethylarenes still rely on classical, harsh Swarts reactions[3] of benzotrichlorides with HF and SF5 that are unsuitable for transformations of molecules containing most functional groups. Most commercial syntheses of trifluoromethyl heteroarenes are conducted by condensation reactions of trifluoroacetic acid derivatives.[4] Although milder than the Swarts reactions, * jhartwig@berkeley.edu.†J. Morstein and H. Hou contributed equally to this work.HHS Public AccessAuthor manuscriptAngew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Published in final edited form as:Angew Chem Int Ed Engl. 2016 July 4; 55(28): 8054–8057. doi:10.1002/anie.201601163.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor Manuscriptthese methods limit the position on the heteroarene at which a trifluoromethyl group can be installed. In both cases, these methods require that the trifluoromethyl group be installed early in a synthetic sequence.More recently, arylboron reagents have been shown to undergo copper-mediated, oxidative trifluoromethylation reactions.[5–11] The ability to form trifluoromethylarenes from arylboronates is important because the arylboronates can be formed by metal-catalyzed borylation of aryl C-H bonds, which occurs with regioselectivities that are controlled by the steric environment at the aryl C-H bonds.[12–13]Yet, organosilanes would be attractive alternatives to arylboronates as precursors to trifluoromethylarenes because silanes are inexpensive[14] and because arylsilanes and heteroarylsilanes are more stable than arylboronates.[15] Recent advances in the regioselective, catalytic silylation of C-H bonds in unactivated arenes and heteroarenes have greatly expanded the accessibility of arylsilanes.[16–19] The silylation of C-H bonds forms arylsilanes with regioselectivities that are enhanced or distinct from those of C-H borylation.[17, 20] The greater selectivity and stability enables the late stage functionalization of arenes and heteroarenes in complex molecules to form arylsilane intermediates that would be unstable as the analogous arylboronate. Thus, if a method to convert arylsilanes to trifluoromethyl arenes could be developed, a method to prepare trifluoromethylarenes from a wide range of arenes and heteroarenes, via the products of C-H bond silylation, would result.We report the trifluoromethylation of readily accessible, stable arylsilanes. These reactions occur with (phen)CuCF3 as the CF3-source and air as the oxidant. The reactions occur with a broad scope of arenes, heteroarenes and active pharmaceutical ingredients and, when combined with C-H bond silylation, provide access to trifluoromethylarenes directly from both simple and complex arenes.To initiate our search for reagents and conditions that lead to the trifluoromethylation of arylsilanes, we investigated conditions reported for the trifluoromethylation of arylboranes.[5–11] We tested this reaction with PhSiMe(OSiMe3)2 (Ph-HMTS for phenyl heptamethyltrisiloxyl) because Ar-HMTS compounds can be formed by the silylation of aryl and heteroaryl C-H bonds. A range of common trifluoromethylation reagents, including both electrophilic CF3-sources (Togni’s reagent[21] and Umemoto’s reagent[22]) and nucleophilic CF3-sources (Ruppert’s reagent[23], Langlois’ reagent[24], Chen’s reagent[25], and (phen)CuCF3[26]) (Scheme 1) were tested as the source of the CF3 group.We conducted reactions with a series of fluoride sources to activate the arylsilane by forming a hypervalent silicon species. The identity of the source of fluoride is likely to be crucial for the activation of the silane; the fluoride must be sufficiently nucleophilic to add to the silane, but it must not trigger rapid cleavage of the carbon-silicon bond. Most combinations of the sources of trifluoromethyl groups and fluoride we tested yielded only trace-amounts or no desired product (see the Supporting Information for a list of these conditions).However, reactions of Ph-HMTS with (phen)CuCF3 (1) and added fluoride in air formed the trifluoromethylarene product in a measurable yield (20%).[27] (phen)CuCF3 is commercially available and is a free-flowing solid that can be stored indefinitely under nitrogen and Morstein et al. Page 2Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor Manuscriptweighed in air. Our group previously reported the trifluoromethylation of aryl iodides[26], aryl boronates[27], and heteroaryl bromides[28] with 1 (Scheme 2). Thus, a convenient method to convert arylsilanes to trifluoromethylarenes would be created if the yields of this initial reaction could be improved.Further studies showed that the trifluoromethylation of Ph-HMTS (Table 1) can occur in high yields with the proper fluoride source and solvent. The reactions with AgF under air occurred in higher yields than those with KF, KHF2, or TBAF. Interestingly, reactions in the presence of benzoquinone formed trifluoromethylbenzene in a higher yield (71%) than with air as oxidant alone (62% yield). The same reaction with benzoquinone under nitrogen gave the product in 42% yield, suggesting that oxygen serves as the oxidant in this system.[29] Finally, an evaluation of these conditions with a series of arylsilanes, including phenyl trimethylsilane, triphenyl silanol, and both dimethoxymethyl and trimethoxy phenylsilane (see the Supporting Information) showed that the yield of trifluoromethylbenzene was highest from the reaction of phenyl hepatmethyltrisiloxane.With these conditions in hand, we explored the scope of the trifluoromethylation of arylsilanes bearing the HMTS group (Table 2). The reaction of arylsilanes with 1 tolerates a wide range of functional groups. Substrates bearing chloride, ether, ketone, ester, amide, nitrile, or trifluoromethyl functionality (3a–f) gave the trifluoromethylarene in good yields. In general, the reactions of more electron-deficient arenes (3a–e) formed the trifluoromethylarene products in higher yields than did reaction with electron-rich arenes (3g). More specifically, the 3,4-dimethylphenylsilane gave the corresponding trifluoromethylxylene in a yield (34%) that was lower than that of most other examples. Reaction of a substrate containing a bromide substituent (3h) also gave the product in a moderate yield (39%), most likely because of competing trifluoromethylation at the aryl bromide.[30]We subsequently explored the scope of the trifluoromethylation of heteroarylsilanes (Table 3). The reaction occurs with five-membered ring heteroarylsilanes, including benzo-fused examples, such as silylindoles. The reaction also occurs with six-membered ring heteroarylsilanes, including those derived from pyridines, pyrazines and quinolines. The ability to conduct the reaction with both electron-rich and electron-poor heteroarenes demonstrates the exceptionally broad scope of the conditions we developed.The trifluoromethylation of heteroarylsilanes is particularly valuable because heteroarylsilanes are less prone to oxidation and protodemetalation than are heteroarylboronates. For example, trifluoromethyl pyrazines (6c) cannot be prepared from an isolated heteroarylboronate because of rapid protodeborylation.[31] Moreover, the combination of C-H bond silylation and trifluoromethylation of the heteroarylsilane provides isomers that complement those generated from direct trifluoromethylation. For example, the reaction of 5a gave 3-trifluoromethylpyrrole in an excellent yield (96%), whereas direct trifluoromethylation with common trifluoromethylation reagents, such as Togni’s reagent,[32] trifluoromethyliodide,[33] and Umemoto’s reagent,[34] form the product from reaction at the 2’-position of pyrrole. Although the borylation of Boc-protected pyrrole Morstein et al. Page 3Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor Manuscriptoccurs at the 3’-position, the yields of trifluoromethyl pyrroles from the corresponding heteroarylboronates are below 50%.[35]Encouraged by the high functional group tolerance and broad substrate scope of the trifluoromethylation of arylsilanes, we evaluated the applicability of our conditions to the late-stage trifluoromethylation of pharmaceutically active molecules (Table 4). We prepared analogs of clopidogrel (antiaggregant) and aripiprazole (antipsychotic) containing HMTS groups under conditions we reported previously.[18] Most striking, the trifluoromethylation of the silylated clopidogrel gave the corresponding trifluoromethylthiophene in good yield (89%), tolerating all four functional groups present with only minor epimerization of the stereocenter (3.8 % of 7 epimerized). The overall yield of 8 for the two-step sequence comprising silylation and trifluoromethylation was 77% (68% isolated, 95.1% ee). Likewise, reaction of the silylated aripiprazole gave the corresponding trifluoromethylarene in 53% yield (41% isolated). Compounds 8 and 10 are not accessible by an analogous sequence comprising borylation and trifluoromethylation. The borylation of clopidogrel gave a mixture of constitutional isomers, as determined by GC and 11B-NMR spectroscopy, and the borylated aripiprazole is unstable; this arylboronate decomposed during purification on silica gel.In conclusion, we report the first method for the trifluoromethylation of arylsilanes. Trifluoromethylation of arylsilanes with 1 proceeds with high functional group compatibility, broad scope of arenes and heteroarenes, and is suitable for the functionalization of pharmaceutically active molecules. Furthermore, the trifluoromethylation of arylsilanes gives access to complex, trifluoromethylated molecules that are inaccessible by the sequence of borylation and trifluoromethylation.Experimental SectionGeneral procedure for the synthesis of trifluoromethyl arenes from arylsilanes with 1: To an oven-dried 20 mL vial was added 1 (0.36 mmol, 1.2 equiv), dry DMF (3.0 mL, stored under nitrogen), AgF (0.60 mmol, 2.0 equiv), p-benzoquinone (0.90 mmol, 3.0 equiv), and arylsilane (0.30 mmol, 1.0 equiv) under air. The suspension was purged with dry air for 30 seconds, and the vial was sealed with a Teflon-lined cap and heated at 50 °C for 16 h under vigorous stirring. The suspension was allowed to cool to room temperature. Water was added to the reaction mixture (5 mL) and extracted with diethylether (3 × 5 mL). The organic layer was washed with a saturated NaCl-solution (1 × 2 mL), dried over anhydrous MgSO4, concentrated, and the residue purified by flash column chromatography or preparative thin layer chromatography. See Supporting Information for detailed procedures.Supplementary MaterialRefer to Web version on PubMed Central for supplementary material.AcknowledgmentsWe thank the NIH (GM-11581201) for support of this work. J. M. thanks the German National Academic Foundation (Studienstiftung) for supporting his research in the Hartwig lab. We thank Michael Mormino for a Morstein et al. Page 4Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor Manuscriptsample of (phen)CuCF3, Jeff Pelton (UC Berkeley NMR facility) for expert technical assistance, and Johnson-Matthey for a gift of [Ir(COD)Cl]2.References1. Purser S, Moore PR, Swallow S, Gouverneur V. Chem. Soc. Rev. 2008; 37:320–330. [PubMed: 18197348] 2. 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Commun. 1989:705–706.26. Morimoto H, Tsubogo T, Litvinas ND, Hartwig JF. Angew. Chem. Int. Ed. 2011; 50:3793–3798.27. Litvinas ND, Fier PS, Hartwig JF. Angew. Chem. Int. Ed. 2012; 51:536–539.28. Mormino MG, Fier PS, Hartwig JF. Org. Lett. 2014; 16:1744–1747. [PubMed: 24621138] 29. Although some reactions without added benzoquinone form the trifluoromethylarene in good yield, most reactions of arenes that are not sensitive to oxidation occurred in about 20% higher yield in the presence of benzoquinone than in the absence of this oxidant. See the Supporting Information for a series of comparisons in the presence and absence of benzoquinone.30. This assertion is supported by the observation of additional Aryl-CF3 compounds by 19F-NMR spectroscopy.31. Sadler SA, Tajuddin H, Mkhalid IAI, Batsanov AS, Albesa-Jove D, Cheung MS, Maxwell AC, Shukla L, Roberts B, Blakemore DC, Lin Z, Marder TB, Steel PG. Organic & Biomolecular Chemistry. 2014; 12:7318–7327. [PubMed: 25116330] 32. Wiehn MS, Vinogradova EV, Togni A. J. Fluorine Chem. 2010; 131:951–957.33. Kino T, Nagase Y, Ohtsuka Y, Yamamoto K, Uraguchi D, Tokuhisa K, Yamakawa T. J. Fluorine Chem. 2010; 131:98–105.Morstein et al. Page 5Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor Manuscript34. Yang J-J, Kirchmeier RL, Shreeve JnM. J. Org. Chem. 1998; 63:2656–2660. [PubMed: 11672133] 35. Reaxys SearchMorstein et al. Page 6Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptScheme 1. Common reagents for the trifluoromethylation of prefunctionalized arenes.Morstein et al. Page 7Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptScheme 2. Copper-mediated trifluoromethylation of arylsilanes.Morstein et al. Page 8Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptMorstein et al. Page 9Table 1Optimization of trifluoromethylation of PhSiMe(OSiMe 3) 2.[a]EntryOxidantAdditiveFluoride(2.0 eq)SolventYield[b]1Air-KFDMF20%2Air-KHF 2DMF38%3Air-AgFDMF62%4Air-TBAFDMF17%5AirKOTMS (2.0 eq)-DMF-6--KHF 2DMF8%7Air-AgFDMSO58%8AirBQ (3.0 eq)[c]AgFDMF71%9-BQ (3.0 eq)[c]AgFDMF42%[a] Reactions run on a 0.1 mmol scale.[b] 19 F-NMR yields are determined with 4-trifluoromethoxyanisole as an internal standard.[c] BQ = p-Benzoquinone.Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptMorstein et al. Page 10Table 2Trifluoromethylation of Arylsilanes.[a,b][a]Reactions run on a 0.1 mmol scale to determine 19F-NMR yields and run on a 0.3 mmol scale to obtain yields of the isolated products. 19F-NMR yields are listed first followed by yields of isolated products in parenthesis.[b]19F-NMR yields are determined with 4-trifluoromethoxyanisole as an internal standard.Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptMorstein et al. Page 11[c]Reaction run without benzoquinone.Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptMorstein et al. Page 12Table 3Trifluoromethylation of Heteroarylsilanes.[a,b][a]Reactions run on a 0.1 mmol scale to determine 19F-NMR yields and run on a 0.3 mmol scale to obtain yields of the isolated products. 19F-NMR yields are listed first followed by yields of isolated products in parenthesis.[b]19F-NMR yields are determined with 4-trifluoromethoxyanisole as an internal standard.[c]Reaction run at 80°C.Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.Author ManuscriptAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptMorstein et al. Page 13Table 4Late-stage trifluoromethylation of pharmaceutically active molecules.[a,b][a]19F-NMR yields are listed first followed by yields of isolated products in parenthesis.[b]19F-NMR yields are determined with 4-trifluoromethoxyanisole as an internal standard.Angew Chem Int Ed Engl. Author manuscript; available in PMC 2017 July 04.

Trifluoromethylation of Arylsilanes with [(phen)CuCF3]

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