Emergency Care System (ECS) is a critical component of health care systems by providing acute resuscitation and life-saving care. As a time-sensitive care operation system, any delay and mistake in the decision-making of these EC functions can create additional risks of adverse events and clinical incidents. The Emergency Care Clinical Decision Support System (EC-CDSS) has proven to improve the quality of the aforementioned EC functions. However, the literature is scarce on how to implement and evaluate the EC-CDSS with regard to the improvement of PHOs, which is the ultimate goal of ECS. The reasons are twofold: 1) lack of clear connections between the implementation of EC-CDSS and PHOs because of unknown quality attributes; and 2) lack of clear identification of stakeholders and their decision processes. Both lead to the lack of a data processing architecture for an integrated EC-CDSS that can fulfill all quality attributes while satisfying all stakeholders’ information needs with the goal of improving PHOs. This dissertation identified quality attributes (PICT: Performance of the decision support, Interoperability, Cost, and Timeliness) and stakeholders through a systematic literature review and designed a new data processing architecture of EC-CDSS, called PICT-DPA, through design science research. The PICT-DPA was evaluated by a prototype of integrated PICT-DPA EC-CDSS, called PICTEDS, and a semi-structured user interview. The evaluation results demonstrated that the PICT-DPA is able to improve the quality attributes of EC-CDSS while satisfying stakeholders’ information needs. This dissertation made theoretical contributions to the identification of quality attributes (with related metrics) and stakeholders of EC-CDSS and the PICT Quality Attribute model that explains how EC-CDSSs may improve PHOs through the relationships between each quality attribute and PHOs. This dissertation also made practical contributions on how quality attributes with metrics and variable stakeholders could be able to guide the design, implementation, and evaluation of any EC-CDSS and how the data processing architecture is general enough to guide the design of other decision support systems with requirements of the similar quality attributes
