Presented with characteristic polyneuropathy and multisystemic manifestations, POEMS syndrome is a rare plasma cell disorder. Vascular endothelial growth factor, secreted by plasmacytoma, is considered responsible for these symptoms. The first symptoms in this patient were arthralgia, distal sensory impairment ascending proximally and motor impairment of distal lower extremities. By immunoelectrophoresis, M protein in serum and urine was detected. In addition to polyneuropathy and monoclonal gammopathy, the patient presented with organomegaly, endocrine dysfunction and skin changes, and was diagnosed as POEMS syndrome. This rare syndrome should be included in the differential diagnosis of acquired neuropathies associated with multisystemic manifestations.POEMS sendromu, polinöropati ve multisistemik tutulum ile seyreden oldukça ender görülen bir plazma hücre diskrazisidir. Semptomlardan plazmasitom tarafından salgılanan vasküler endotelyal büyüme faktörü sorumlu tutulmaktadır. Distal simetrik sensörimotor polinöropati kliniği ile başvuran, yanı sıra organomegali, endokrin bozukluk ve deri değişiklikleri de olan olgunun immünelektroforezinde serum ve idrarda M proteini saptanması nedeniyle POEMS sendromu düşünülmüştür. Edinsel nöropatilerin ayırıcı tanısında akla gelmesi gereken bu sendrom ender görülmesi nedeniyle sunulmuştur
