Seventy-seven patients with sarcoidosis followed in our department evaluated retrospectively and the study continued prospectively. Depending on the radiologic findings, 26 (33.8%) of these cases were considered to be in stage 1, 47 (61.0%) were in stage 2 and 4 (5.2%) were in stage 3. Erythema nodosum was found in 29 (37.7%) cases; 15 (51.7%) of whom were stage 1, 13 (44.8%) were stage 2 and 1 (3.4%) was stage 3. There was peripheral lymphadenopathy in 8 (10.4%) cases. Bronchoscopy was performed in 68 cases and 55 found to be normal. BAL was determined in 50 of those to whom bronchoscopy had been performed. Mean BAL lymphocyte rate was found to be 32.2% and it was 36.1 % in stage 1, 31.1% in stage 2 and 22.2% in stage 3. Diagnosis of sarcoidosis was confirmed with histopathologic examination in 48 cases and with BAL and other clinical signs in the others. It was confirmed with parenchymal biopsy in 15 cases, with scalene lymph no-de biopsy in 8 cases, with bronchial mucosa biopsy in 5, with transcarinal needle aspiration biopsy in 5, with video-assisted thoracoscopic surgery in 4, with right supraclavicular lymph node biopsy in 3 and with skin biopsy in 2 cases. Tuberculin skin test was performed in 67 cases and was found to be negative in 51 (76.1%). Serum ACE levels were checked in 11 cases and found to be high in 7 of them (63.6%) (mean: 21.9). Two of 55 cases who had neurologic examination, 3 of 60 cases who had fundoscopy were found to have pathologic findings.Kliniğimizde takip edilen 77 sarkoidoz olgusu retrospektif olarak değerlendirilmiş, çalışma prospektif olarak devam etmiştir. Bu olguların 54'ü kadın, 23'ü erkek olup, ortalama yaş 42.97 (21-82)'dir. Radyolojik bulguları ile olguların 26 (%33.8)'sı evre l, 47 (%61.0)'si evre 2 ve 4 (%5.2)'ü evre 3 olarak kabul edilmiştir. evre l'de 15 (%51.7), evre 2'de 13 (%44.8), evre 3'te 1 (%3.4) olmak üzere toplam 29 (%37.7) olguda eritema nodosum gözlenmiştir. Sekiz (%10.4) olguda periferik lenfadenopati saptanmıştır. Altmışsekiz olguya bronkoskopi yapılmış, 557 normal olarak değerlendirilmiştir. Bronkoskopi yapılan olguların 50'sinde bronkoalveoler lavaj (BAL)'da hücre ayrımı yapılabilmiştir. BAL lenfosit yüzdesi, ortalama %32.2 (2-72) olup evre l 'de %36. l, evre 2'de %31.1, evre 3'te %22.2 oranındadır. Sarkoidoz tanısı 48 olguda histopatolojik olarak, diğer olgularda ise BAL ve klinik bulgular ile konulmuştur. Onbeş olguda parankim biyopsisi, sekiz olguda skalen lenf bezi biyopsisi, beş olguda bronş mukoza biyopsisi, beş olguda transkarinal ince iğne aspirasyon biyopsisi, dört olguda video yardımlı torakoskopik cerrahi, üç olguda sağ supraklaviküler lenf bezi biyopsisi, iki olguda deri biyopsisi ve tanı elde edilmiştir. Altmışyedi olguya tüberkülin deri testi yapılmış, olguların 51 (%76.1)'inde negatif bulunmuştur. Serum IgG ve IgM 5 (%]0.6) olguda, serum Ca 2 (%1.4) olguda yüksek, diğer olgularda normal değerlerde bulunmuştur. Onbir olguda serum ACE düzeyi bakılmış, 7 (%63.6)'sinde yüksek bulunmuştur (ortalama 21.9 U/L). Nörolojik muayene yapılan 55 olgunun 2 (%3.6)'sinde, göz muayenesi yapılan 60 olgunun ise 3 (%5.0)'ünde patoloji saptanmıştır
