This Report is based on research and analysis undertaken by the Centre for Global Health Research (CGHR) in collaboration with the Registrar General of India (RGI) and the Center for Disease Dynamics, Economics & Policy (CDDEP), applying cost-effectiveness methodologies developed in the context of the Disease Control Priorities Project – 2 (http://www.dcp-3) to data on causes of death in Karnataka. New data indicates that several hundred thousand people in Karnataka are dying prematurely from easily preventable causes