Retrospective case-control study genes related to bone metabolism that justify the condition of periodontal disease and failure of dental implants in patients with down syndrome
Abstract: Down syndrome patients show success rates in dental implants much lower than those
observed in the general population. This retrospective case-control study aimed to identify possible
genes that are related to the regulation of inflammatory responses and bone metabolism related to
periimplantitis and implant loss, as well as genes related to bone quality. This process involved
using the functional analysis of the gene expression software Transcriptome Analysis Console (TAC
version 4.0 Applied BiosystemsTM, Thermo Fisher Scientific, Waltham, MA, USA) and a search for
possible candidate genes involved. The focus was placed on the 93 genes related to periodontitis,
periimplantitis, bone loss, implant loss, and genes related to bone quality and regulators underlying
the establishment and maintenance of osseointegration. Five genes showed statistically significant
results (p < 0.05) in our comparison. Four of them, IL1B (p = 0.023), IL1RN (p = 0.048), BGLAP
(p = 0.0372) and PTK2 (p = 0.0075) were down-regulated in the periodontal disease and implant
rejection group, and only one was overexpressed: FOXO1A (p = 0.0552). The genes with statistically
significant alterations described in this article determine that the group of Down syndrome patients
with periodontal disease and implant failure is a group of patients genetically susceptible to suffering
from both conditions together