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Prevalence of chronic HCV infection in EU/EEA countries in 2019 using multiparameter evidence synthesis
Authors
Mária Avdičová
Maria Axelsson
+63 more
Benjamin Bluemel
Anders Boyd
Cécile Brouard
Henrikki Brummer-Korvenkontio
Martin Busch
Peer Brehm Christensen
Anna Rita Ciccaglione
Susan Cowan
Julia del Amo
Asuncion Diaz
Sandra Dudareva
Erika Duffell
Ziad El-Khatib
Magnús Gottfreðsson
Ilias Gountas
Konstantinos Gountas
Ligita Jancoriene
Jana Kerlik
Sofieke Klamer
Irena Klavs
Hilde Kløvstad
Loreta A. Kondili
Mirjana Lana Kosanovic Licina
Emese Kozma
Amrei Krings
Irene Kászoni-Rückerl
Josefine Lundberg Ederth
Marek Maly
Rui Tato Marinho
Mojca Maticic
Tanya Melillo
Zsuzsanna Molnár
Laure Mortgat
Niamh Murphy
Vratislav Nemecek
Tatjana Nemeth Blazic
Raina Nikiforova
Georgios Nikolopoulos
Georgia Nikolopoulou
Diana Nonković
Eline Op de Coul
Filippo Maria Pericoli
Els Plettinckx
Odette Popovici
Renate Putnina
Magdalena Rosińska
Kristi Rüütel
Irene Schmutterer
Carole Seguin-Devaux
Thomas Seyler
Gyde Steffen
Małgorzata Stępień
Barbara Suligoi
Fanitsa Theophanous
Christos Thomadakis
Maria Elena Tosti
Cristina Valente
Dominique Van Beckhoven
Marc van der Valk
Thomas Vanwolleghem
Tonka Varleva
Robert Whittaker
Ruth Zimmermann
Publication date
1 January 2023
Publisher
Doi
Cite
Abstract
Publisher Copyright: © 2023 The Author(s)Background: Epidemiological data are crucial to monitoring progress towards the 2030 Hepatitis C Virus (HCV) elimination targets. Our aim was to estimate the prevalence of chronic HCV infection (cHCV) in the European Union (EU)/European Economic Area (EEA) countries in 2019. Methods: Multi-parameter evidence synthesis (MPES) was used to produce national estimates of cHCV defined as: π = πrecρrec + πexρex + πnonρnon; πrec, πex, and πnon represent cHCV prevalence among recent people who inject drugs (PWID), ex-PWID, and non-PWID, respectively, while ρrec, ρex, and ρnon represent the proportions of these groups in the population. Information sources included the European Centre for Disease Prevention and Control (ECDC) national operational contact points (NCPs) and prevalence database, the European Monitoring Centre for Drugs and Drug Addiction databases, and the published literature. Findings: The cHCV prevalence in 29 of 30 EU/EEA countries in 2019 was 0.50% [95% Credible Interval (CrI): 0.46%, 0.55%]. The highest cHCV prevalence was observed in the eastern EU/EEA (0.88%; 95% CrI: 0.81%, 0.94%). At least 35.76% (95% CrI: 33.07%, 38.60%) of the overall cHCV prevalence in EU/EEA countries was associated with injecting drugs. Interpretation: Using MPES and collaborating with ECDC NCPs, we estimated the prevalence of cHCV in the EU/EEA to be low. Some areas experience higher cHCV prevalence while a third of prevalent cHCV infections was attributed to PWID. Further efforts are needed to scale up prevention measures and the diagnosis and treatment of infected individuals, especially in the east of the EU/EEA and among PWID. Funding: ECDC.Peer reviewe
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