Comparison of Iomeprol 300 and 350 mgI/ml Syringe Preparations for Contrast-Enhanced Helical Computed Tomography of the Liver Using Bolus-Tracking Technology
Purpose: To evaluate contrast enhancement with iomeprol in helical computed tomography(CT)
using bolus-tracking technology.
Method: Helical CT examinations were performed on 114 patients using 100 ml of iomeprol
administered via either a 300 mgI/ml syringe or a 350 mgI/ml syringe. After nonenhanced CT was
performed, contrast-enhanced CT scans were obtained at optimal times during three phases, the
early, late, and delayed phases, using bolus-tracking technology while infusing the contrast medium.
Regions of interest were determined for the observed transverse sections of the aorta and liver, and
the contrast index that was used for plotting time-density curves was defined as the difference in CT
density before and after the administration of iomeprol. Time-density curves were plotted by body
weight group to evaluate how the contrast enhancement was affected by different concentrations of
the contrast medium.
Results: When time-density curves obtained using iomeprol preparations containing different
iodine concentrations for the different body weight groups were compared, the contrast
enhancement tended to be greater for the 350 mgI preparation than the 300 mgI preparation.
Conclusion: Contrast-enhanced CT can be performed with a 300 mgI preparation of iomeprol in
patients weighing less than 60 kg; whereas a 350 mgI preparation is preferable for patients weighing
60 kg or more
