We report the combined therapeutic effect of subcutaneous injection of octreotide and oral
glucose administration to monochloroacetic acid exposed rats.
The control rats group was subcutaneously injected with 80 mg/kg sodium monochloroacetate
and infused with 2 mL/hour 10% glucose solution for 10 hours 60 minutes after exposure. Group
A was given 2 g/kg oral glucose after exposure, and then infused with glucose as control. Group B
was given 2 g/kg oral glucose and a subcutaneous injection of 30 µg/kg octreotide after exposure,
and then infused with glucose as control.
The 14-day survival rate was 0.35 (control), 0.50 (group A) and 0.90 (group B). The blood
glucose of group B increased to 188 mg/dl at the beginning of the glucose infusion, significantly
higher than group A. Although there were significant differences in the lactate levels between the
3 groups, the levels were not abnormally high.
In conclusion, our study suggests that it is important to elevate the blood glucose levels within
60 minutes after monochloroacetic acid exposure. In addition, a combination of subcutaneous
octreotide and oral glucose is advantageous to maintain high blood glucose level at early stages
after exposure and may be an effective therapy for monochloroacetic acid intoxication
