Layered software architecture has been used to increase code portability and reduce development times during the Systems Development Life Cycle (SDLC). The main objective of the EMIDSS-4 project is to develop a reliable and scalable hardware and software layered architecture for data acquisition in nanosatellites. An iterative hardware/software co-design approach was employed, transitioning from an FPGA architecture to an NXP-based microcontroller. The results demonstrate that the new architecture provides continuous and adaptable data acquisition capabilities, enhancing the long-term viability of the project. In conclusion, this study contributes to the field of space exploration and lays the foundation for future research in nanosatellites.ITESO, A. C