Neurological disorders are a frequent cause of hospitalization in the elderly. Herein, wdescribe a case of acute disseminated encephalomyelitis (ADEM) in a 68-year old woman. Medical history, neurological signs, Magnetic Resonance Imaging (MRI), Cerebrospinal Fluid (CSF) studies and screening for infectious agents are needed for differential diagnosis. We started treatment with high-dose intravenous corticosteroids reaching good results