The aim of this paper is to investigate the impact of domestic investment, innovation and R&D on economic growth in the case of MENA Countries over the period 2002 – 2021. By using gravity model statistic, found that domestic investment has a positive impact on economic growth. However, innovation and R&D have not any impact on economic growth. It is true that our results indicate that domestic investments are a source of economic growth, but the lack of R&D investments, the lack of collaboration between universities and businesses, the low quality of education and regulatory obstacles are the causes that make innovation and investment in R&D have an adverse impact on economic growth. MENA countries need to invest more in R&D, promote cooperation, improve the quality of education and ease regulatory barriers
