Aim: Lactoferrin (Lf) is an antimicrobial and iron
chelator glycoprotein contained in exocrine
secretion, including saliva, and in secondary
granules of neutrophil granulocytes. Lf performs
its antibacterial and antiviral action through two
pathways: the first deprives bacteria of the iron
they need for their reproduction and for biofilm
formation; the second contributes to restore the
inflammatory homeostasis which is essential for
tissue health modulating the level of cytokines,
like IL-6. The study intends to propose the use
of systemic and in situ Lf effectiveness in the
healing of oral mucosa and bone tissue affected
by medication-related ostenecrosis of the jaw
(MRONJ), after surgical excision or spontaneous
elimination of necrotic bone
