Supplementary Material for: Ocular metastasis as first presentation of large-cell neuroendocrine carcinoma

Abstract

We report a rare case of an aggressive large-cell neuroendocrine lung tumour which presented with ocular metastasis. A 70-year-old lady presented with a four-week history of left eye pain and photophobia. Ocular examination revealed left-sided episcleritis and she was treated with topical lubricants and steroids. However, she re-presented six months later with recurrent left eye symptoms, and was found to have an iris stroma amelanotic lesion, posterior synechiae, 360-degrees rubeosis iridis, raised intraocular pressure and trace vitreous inflammation. Ultrasound biomicroscopy revealed a left thickened iris with an associated ciliary body lesion. Sarcoid-related ocular inflammation was suspected, but a computed tomography (CT) scan of the lung revealed an incidental right upper lobe lesion. Histology from a trans-corneal iris biopsy showed a high-grade neuroendocrine carcinoma, and the diagnosis of metastatic lung large-cell neuroendocrine carcinoma was confirmed via high-resolution CT-scan, positron emission tomography scan and CT-guided lung biopsy. She was given multiple courses of different chemotherapy regimens along with palliative radiotherapy. However, the tumour and its metastases continued to progress and she passed away four years after her initial presentation. Ocular metastatic large-cell neuroendocrine carcinoma is rare, and first presentation with ocular metastasis is even rarer. This case highlights the importance of early detection of ocular metastases in order to hasten oncological treatment. A low threshold for systemic investigations and ophthalmology referral in cases of unexplained, refractory ocular symptomatology is essential given the heterogenous presentation, rarity and poor prognosis of these tumours, even with maximal treatment