University of Thi-Qar, College of Agriculture and Marshes
Abstract
The present study aimd to estimate the changes in lipid profile depend on dosage amount of two AEDs ,Phenytoin (PHT) and Carbamazepine (CBZ) , and make a comparison between them in rats. A 30 healthy male Wistar rats (150-200 g) ( subdivide to five groups ) first group was control , the second and third groups received (50 mg\kg and 100 mg\kg) of Phenytoin respectively, fourth and fifth groups received (25 mg/kg and 50 mg/kg) of Carbamazepine respectively. Serum total cholesterol (TC), triglycerides (TGs) and High-density lipoprotein (HDL) levels were measured after 20 days period of treating, Low-density lipoprotein (LDL) and Very low-density lipoprotein (VLDL) was calculated also. Our data revealed that, the administration of PHT (50 mg\kg) and CBZ (25 mg\kg) did
