Introduction
There is a increasing amount of verification supporting
the view that oxidative stress is involved and plays a important
role in the pathophysiology of primary hypertension.
Objective:
This research examines the association of blood
pressure with blood oxidative stress-related parameters in
normotensive and hypertensive subjects.
Materials & Methods:
A cross-sectional design was applied to 32 hypertensive
patients and 33 healthy normotensive subjects. All subjects
were men between the ages of 35 and 60 years. Cases of
dyslipidemia, diabetes mellitus, obesity, smoking and those
taking medication were excluded from the study. In
erythrocyte lipid peroxidation (malondialdehyde) and reduced/
oxidized glutathione ratio (GSH/GSSG) were determined.
Parameters measured in the plasma of test subjects were
plasma antioxidant status, plasma vitamin C, vitamin E, lipid
peroxidation (8-isoprostane), blood pressure modulators
renin, aldosterone, endothelin-1, and homocysteine.
Results: Daytime systolic and diastolic blood pressures
of hypertensives were negatively correlated with plasma
antioxidant capacity (r=–0.54, p=0.001 and r=–0.60, p<0.001),
plasma vitamin C levels (r=–0.47, p=0.006 and r=–0.43, p=0.01),
erythrocyte activity of antioxidant enzymes, and erythrocyte
GSH/GSSG ratio, with hypertensives showing higher levels of
oxidative stress.
Conclusion: Blood pressures showed a positive
correlation with both plasma and urine 8-isoprostane. These
results show a strong association between blood pressure and
some oxidative stress-related parameters and propose a
probable role of oxidative stress in the pathophysiology of
essential hypertensio
