In turboprop aircraft, the low-frequency noise field created by the propellers is the major contributor to the interior vibro-acoustic field, which determines a passenger’s discomfort. This paper deals with the experimental assessment of an active noise control (ANC) system for cabin seat headrests using two loudspeakers placed on both sides of the passenger’s head to create a local zone of quiet around the passenger’s ears. To deal with time-varying disturbances, the developed ANC system utilized a two-input-two-output filtered-X LMS algorithm developed in MATLAB/Simulink and implemented on a DSPACE control board to drive the secondary speakers and cancel the unwanted low-frequency noise components. The performance of the active headrest was investigated through real-time experimentation involving sensors, actuators, and electronic devices. The test results showed that up to approximatively 20 dB of sound attenuation could be realized in the passenger’s ears over a narrowband sound field replicated under laboratory conditions. Such achievements represent an excellent starting point toward practical applications in the design of more comfortable and acoustically efficient aircraft cabin seats