Konstanty-Kalandyk, Janusz

Kopytek, Magdalena

Natorska, Joanna

Undas, Anetta

Ząbczyk, Michał

Via Medica Journals

Supplementary material   Kopytek M, Konstanty-Kalandyk J, Ząbczyk M et al. Valvular expression of factor XI correlates with valve calcification and aortic stenosis severity. Kardiol Pol. 2023.  Please note that the journal is not responsible for the scientific accuracy or functionality of any supplementary material submitted by the authors. Any queries (except missing content) should be directed to the corresponding author of the article.  Table S1. Baseline characteristic of patients with aortic stenosis (AS)               Data presented as numbers (percentages), mean and (SD) or medians (interquartile range). A P-value of <0.05 was considered statistically significant Abbreviations: ACE-i, angiotensin converting enzyme inhibitors; BMI, body mass index; CRP, C-reactive protein  Variable AS patients (n = 20)             Age, years 64 (9.6) Male, n (%) 12 (60) BMI, kg m-2 28.4 (5.0) Risk factors, n (%)  Arterial hypertension 18 (90) Hypercholesterolemia 14 (70) Current smoking 4 (20) Medications, n (%)  Beta-blockers 18 (90) Acetylsalicylic acid 16 (80) ACE-i 16 (80) Statins 14 (70) Echocardiographic parameters  Peak transvalvular velocity, m/s 4.6 (4.5–5.0) Mean gradient, mm Hg 54 (46–68) Maximal gradient, mm Hg 83 (80–100) Aortic valve area, cm2 0.8 (0.7–0.9) Laboratory investigations  Fibrinogen, g/l 3.2 (0.7) Creatinine, µmol/l 82 (19.0) CRP, mg/l 1.1 (1.0–3.1) Glucose, mmol/l 5.2 (5.0–5.7) Total cholesterol mmol/l 4.2 (0.9) LDL-cholesterol, mmol/l 2.6 (2.0–3.0) HDL-cholesterol, mmol/l 1.3 (0.3) Triglycerides, mmol/l 1.1 (0.9–1.4)  Figure S1. Associations between valvular factor (F)XI expression and disease severity in aortic stenosis patients. The scatterplots show correlations between valvular FXI expression and: A. Peak transvalvular velocity (Vmax); B. Mean transvalvular pressure gradient (PGmean); C. Maximal transvalvular pressure gradient (PGmax); D. aortic valve area (AVA)  

Valvular expression of factor XI correlates with valve calcification and aortic stenosis severity

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Valvular expression of factor XI correlates with valve calcification and aortic stenosis severity

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