Objective: To investigate the clinical effect of endoscopic sinus surgery on fungal sinusitis. Methods: 100 patients who came to our hospital for treatment from January 2019 to January 2022 were selected as the study subjects. The patients were divided into two groups using a random number table method, with 50 patients in each group. They were the experimental group and the control group. Patients in the control group can be treated with traditional Caldwell Luc surgery. The experimental group was treated with endoscopic sinus surgery. The total effective rate, specific airway resistance, olfactory function, incidence of postoperative infection, and recurrence rate of the two groups were compared. Results: The total effective rate of surgery in the experimental group reached 98%. Compared with the control group, the total effective rate of surgery was 78%. The difference was statistically significant (P<0.05). There was no statistically significant difference between the postoperative infection rate (2.53% vs 8.57%) and recurrence rate (2.86% vs 5.71%) between the two groups (P>0.05). Conclusion The treatment of fungal sinusitis with endoscopic sinus surgery is effective, which can significantly reduce nasal airway resistance, improve patients' olfactory function, and reduce postoperative infection and recurrence
