Perfused porous hydrogel scaffold: modeling hydrodynamics and species transport

Abstract

International audiencePresent approach well suited to predict both (i) fluid flow in the macroporosity of the scaffold stack, (ii) the oxygen state experienced by the cells within the scaffolds Next: Co-culture of human umbilical vein endothelial cells and human mesenchymal stem cells Optical coherence tomography (OCT) to get a better spatial resolution and capture the microporosity of the porous hydrogel scaffolds Context LBM scheme and boundary conditions Custom-made perfusion bioreactor Hydrodynamics and oxygen transport