Neurodegenerative disorders (NDD) are age-related condition
characterized by a progressive decline in brain functions. This
condition has influenced more than 8% of the adult population
worldwide, predominately with Alzheimer's disease (AD).
Currently, NDD treatment is addressed to relieve existing
symptoms, so the effective medication is urgently needed.
Flavonoids offer remarkable pharmacological properties
applicable to be neuroprotective agents. This study aimed to
determine the activity of flavonoid compounds against AD by
inhibiting acetylcholinesterase (AChE) and monoamine oxidase
B (MAO-B) receptors. The method utilized molecular docking
studies with the AutoDockTools 4.2.6 program. Analysis of
pharmacochemical properties were carried out using
SwissADME, while pharmacokinetics and toxicity were
examined in the pkCSM web server. The results indicated that α-
amyrin and pinoresinol were the most potential AChE and MAO-
B inhibitor, respectively. The compounds have lower energy
binding values, inhibition constants, and high percentage of
similarity with amino acid residues in the ligand native. Analysis
of the physicochemical and pharmacokinetic properties showed
that these two compounds are acceptable to the body and
provides no toxicity. This study demonstrated that the
compounds α-amyrin and pinoresinol might potential to be
therapeutic agent which primarily act to inhibit AChE and MAO-
B in AD progression
