Platform presentation at the SETAC Europe 33rd Annual Meeting, Dublin Session: 3.20 - PMT/vPvM substances: Assessment, Management and Regulation, 04 May 202

Arp, Hans Peter

AURICH, Dagny

Hale, Sarah

SCHYMANSKI, Emma

Sims, Kerry

Open Repository and Bibliography - Luxembourg

Chemical Stripes – Visualizing Chemical Trends of the Past Influencing TodayDagny Aurich1, Hans Peter Arp2,3, Sarah Hale2, Kerry Sims4, Emma L. Schymanski11 Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Avenue du Swing 6, L-4367 Belvaux, Luxembourg2 Norwegian Geotechnical Institute (NGI), P.O. Box 3930, Ullevål Stadion, 0806 Oslo, Norway3 Department of Chemistry, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway4 Environment Agency, Horizon House, Deanery Road, Bristol, BS1 5AHE-mail contact: dagny.aurich@uni.lu Slides @ DOI:10.5281/zenodo.7885032Platform presentation at the SETAC Europe 33rd Annual Meeting, DublinSession: 3.20 - PMT/vPvM substances: Assessment, Management and Regulation, 04 May 2023Introduction – Today I will talk about…2• The importance of investigating chemical history • Why quick action is needed• How patent data is a useful resource for this investigation• How visualization can help to raise awareness (Chemical Stripes)Introduction – Reconstructing Chemical History3• Investigating chemical history foroHealth Risks (long-term)oEnvironmental RisksoLegal Action• Analysing historical records / dataIntroduction – Reconstructing Chemical History4 Avoiding new ‘Silent Springs’* Can inform policy decisions related to environmental regulations &public health protection0.00E+005.00E+061.00E+071.50E+072.00E+07No of chemicals registered per year in the CAS registry* Arp HPH, Aurich D, Schymanski EL, Sims K, Hale SE. Avoiding the Next Silent Spring: Our Chemical Past, Present, and Future. 2023. doi:10.1021/acs.est.3c01735Introduction – The Why and How5• Quick action is necessary:o Delay makes information less accurateo Health impacts may not (yet) manifest (for) decades after exposureo May help prevent further exposure & minimize the risk of future health impactsIntroduction – The Why and How6• Patent data as a valuable resource:o Detailed record of the development / use of chemicals over time+ Information on production methods, uses & safety concerns Identify potential sources of exposure & inform risk assessmentsIntroduction – The Use of Data Visualisation7• Warming or climate stripesCommunicate complex environmental data in a simple, intuitive waySee long-term trends and changesUse of colour for quick interpretation (broad audience)Image ref: https://showyourstripes.info/s/globeIntroduction – The Use of Data Visualisation8• Extension to other types of environmental data Sea level riseImage ref: https://twitter.com/selwynox/status/1148154450672050176, 0 25 cmIntroduction – The Use of Data Visualisation9• Extension to other types of environmental dataBiodiversity decreaseImage ref: https://findingnature.org.uk/2022/08/10/biodiversity-stripes/Introducing Chemical Stripes 10• Use of the climate stripes concept• Use of patent data from :Show trends and changes (estimated) chemical use that may have impacted public health & environmentChemical Stripes Example: PFOSR package 11• R package chemicalStripes available on GitLab: Input:                     Chemical Identifier (opt.: date range) Retrieving compound information using webchem Automated extraction of patent data from Processing patent data (big data files) Creating and saving ‘stripes plot’ chemical_stripes(pc_id, date_range = c(1960, 2021), colorblind = FALSE)defaulthttps://gitlab.uni.lu/eci/chemicalstripesPatent Download12 Using the                           functionalitiesGenX : 256 patentsR package: Example 13https://gitlab.uni.lu/eci/chemicalstripesR package: Example 14https://gitlab.uni.lu/eci/chemicalstripesChemical Stripes Visualization - Extended15• Summarized chemical stripes for PFAS with accompanying regulation dates and cumulative Chemical Abstract Service registry numbers:1913                1930                    1950                    1970                     1990                    2010    2021Stockholm convention listing datescumulative CAS numbers200 Mio100 Mio0 PFOSPFOAPFHxS16• Many compounds detected in the environment classified as being persistent and mobile (often even toxic)• Can be used for different sets of chemicalse.g. TriazinesChemical Stripes Visualization - Extended17• Overall trend in rising patent and chemical numbers (databases)Alarming:  Increase of specific chemical classes relevant to planetary boundary threats Long time frame between suspecting a chemical to be a threat and regulatory action taking place? !                     §Arp HPH, Aurich D, Schymanski EL, Sims K, Hale SE. Avoiding the Next Silent Spring: Our Chemical Past, Present, and Future. 2023. doi:10.1021/acs.est.3c01735Chemical Stripes Visualization - ExtendedUse of Chemical Stripes Visualization 18• Looking at specific substance classes can raise awareness:What went wrong in the past?What actions could have been taken earlier for better regulation in the future?• Need for Action:o Identify specific hazards and risks not fully understood/addressed in the pastoHighlight regulatory gapsoPromote effective risk assessment and managementoBuild public awareness and support for safer / more sustainable chemical useUse of Chemical Stripes Visualization 19• Can support the interpretation of (chemical) data  Stripes illustrate the trend of increasing numbers of potentially threatening chemicals in the environment• Can help identify possible changes due to regulatory measures PFOA listed in 2019 in the Stockholm Convention (Elimination)Conclusion 20• Investigating chemical history can help with environmental regulations & public health protection• Quick action is needed especially regarding PMT chemicals• Visualizations are an effective tool to raise awareness• Chemical Stripes visualizations (R package) show Trend of increasing chemical numbers Possible regulatory effectsEven for your favourite chemicals….caffeineAcknowledgements21THANK YOU!https://orcid.org/0000-0001-8823-0596dagny.aurich@uni.luReferences22• WIPO - World Intellectual Property Organization. Accessed October 24, 2022. https://www.wipo.int/• CAS REGISTRY. CAS. Accessed August 2, 2021. https://www.cas.org/cas-data/cas-registry• Kim S, Chen J, Cheng T, et al. PubChem 2023 update. Nucleic Acids Research. 2023;51(D1):D1373-D1380. doi:10.1093/nar/gkac956• 2018 visualisation update | Climate Lab Book. Accessed October 25, 2022. https://www.climate-lab-book.ac.uk/2018/2018-visualisation-update/• Miles. Biodiversity Stripes – A Journey from Green to Grey. Finding Nature. Published August 10, 2022. Accessed October 24, 2022.https://findingnature.org.uk/2022/08/10/biodiversity-stripes/• Persson L, Carney Almroth BM, Collins CD, et al. Outside the Safe Operating Space of the Planetary Boundary for Novel Entities. Environ Sci Technol. 2022;56(3):1510-1521. doi:10.1021/acs.est.1c04158www.dou• Stockholm Convention - Home page. Accessed October 25, 2022. http://www.pops.int/• Schymanski, Emma, Wang, Zhanyun, Wolf, Raoul, Arp, Hans Peter. S90 | ZEROPMBOX1 | ZeroPM Box 1 Substances. Published online January 15, 2022.doi:10.5281/ZENODO.5854251• Mohammed Taha H, Aalizadeh R, Alygizakis N, et al. The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspectscreening in high resolution mass spectrometry. Environmental Sciences Europe. 2022;34(1):104. doi:10.1186/s12302-022-00680-6• ‘Dark Waters’ and PFOA – FAQ. CHEM Trust. Published February 26, 2020. Accessed November 14, 2022. https://chemtrust.org/dark-waters-and-pfoa-faq/• Arp HPH, Aurich D, Schymanski EL, Sims K, Hale SE. Avoiding the Next Silent Spring: Our Chemical Past, Present, and Future. Environ Sci Technol. Published online April13, 2023:acs.est.3c01735. doi:10.1021/acs.est.3c01735

Chemical Stripes – Visualizing Chemical Trends of the Past Influencing Today

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Chemical Stripes – Visualizing Chemical Trends of the Past Influencing Today

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