The authors
state that there are no conflicts of interest to disclose. This
publication was funded by the CNIC. The CNIC is supported
by the Instituto de Salud Carlos III (ISCIII), the Ministerio de
Ciencia e Innovación (MCIN) and the Pro CNIC Foundation,
and is a Severo Ochoa Center of Excellence (grant CEX2020-
001041-S funded by MICIN/AEI/10.13039/501100011033).S