Bahuguna P

Brown R

Burgess K

Campbell H

Campbell IH

Creasy F

Fisher C

Gibbs MC

Grossi H

Kamenska I

Madowcroft B

McIntosh E

McLellan A

Mitchell-Grigorjeva M

Moses T

Needham N

Norrie J

Rigby BP

Simpson SA

Smith DJ

Thompson G

Thrippleton MJ

English

BackgroundRecent evidence from case reports suggests that a ketogenic diet may be effective for bipolar disorder. However, no clinical trials have been conducted to date.AimsTo assess the recruitment and feasibility of a ketogenic diet intervention in bipolar disorder.MethodEuthymic individuals with bipolar disorder were recruited to a 6–8 week trial of a modified ketogenic diet, and a range of clinical, economic and functional outcome measures were assessed. Study registration number: ISRCTN61613198.ResultsOf 27 recruited participants, 26 commenced and 20 completed the modified ketogenic diet for 6–8 weeks. The outcomes data-set was 95% complete for daily ketone measures, 95% complete for daily glucose measures and 95% complete for daily ecological momentary assessment of symptoms during the intervention period. Mean daily blood ketone readings were 1.3 mmol/L (s.d. = 0.77, median = 1.1) during the intervention period, and 91% of all readings indicated ketosis, suggesting a high degree of adherence to the diet. Over 91% of daily blood glucose readings were within normal range, with 9% indicating mild hypoglycaemia. Eleven minor adverse events were recorded, including fatigue, constipation, drowsiness and hunger. One serious adverse event was reported (euglycemic ketoacidosis in a participant taking SGLT2-inhibitor medication).ConclusionsThe recruitment and retention of euthymic individuals with bipolar disorder to a 6–8 week ketogenic diet intervention was feasible, with high completion rates for outcome measures. The majority of participants reached and maintained ketosis, and adverse events were generally mild and modifiable. A future randomised controlled trial is now warranted

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<strong>Pilot study of a ketogenic diet in bipolar disorder</strong>

https://eprints.ncl.ac.uk/fulltext.aspx?url=294691/9FF42722-975C-468E-974F-079F97B5DC73.pdf&pub_id=294691

<strong>Pilot study of a ketogenic diet in bipolar disorder</strong>

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