Theoretical investigation of the differences in the ionization and hydrophobicity of the MAO A active site with and without serotonin

Abstract

Monoamine oxidase (MAO) is a mitochondrial flavoenzyme which plays an essential role in the regulation of levels of biogenic monoamines in the human body and exists in two forms, MAO A and MAO B. Differences of two enzymes led to different therapy indications for MAO A and MAO B inhibitors [1]. ...Structure-based drug design for diagnosis and treatment of neurological diseases COST CM110