Includes abstract.
Includes bibliographical references (leaves 131-147)

Somers, Sarin J

English

Cape Town University OpenUCT

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.

A CaPful of mechanisms regulating the mitochondrial permeability transition.

A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice.

A fresh look at reperfusion injury.

A physiological role of the adenosine A3 receptor: sustained cardioprotection.

A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II).

A simplification of the protein assay method of Lowry et al. which is more generally applicable.

A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury.

Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.

Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes.

Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes.

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?

Adenosine A1 agonist at reperfusion trial (AART): results of a three-center, blinded, randomized, controlled experimental infarct study.

Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD)

Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism.

Adenosine: trigger and mediator of cardioprotection.

Aging reduces the cardioprotective effect of ischemic preconditioning in the rat heart.

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

An essential role of the JAK-STAT pathway in ischemic preconditioning.

Antiinflammatory properties of HDL.

Beta endorphin release in patients after spontaneous and provoked acute myocardial ischaemia.

Beta-endorphins during coronary angioplasty in patients with silent or symptomatic myocardial ischemia.

Biochemical and pharmacological control of the multiplicity of coupling at Gprotein-coupled receptors.

Biochemical properties of hormone-sensitive adenylate cyclase.

Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.

Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS.

Bradykinin protects against infarction but does not mediate ischemic preconditioning in the isolated rat heart.

Bradykinin protects the rabbit heart after cardioplegic ischemia via NO-dependent pathways.

Braunwald's heart disease: A textbook of cardiovascular medicine:

Calcium-independent phospholipase A(2) mediates CREB phosphorylation and c-fos expression during ischemia.

Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling.

Canine myocardial adenosine and lactate production, oxygen consumption, and coronary blood flow during stellate ganglia stimulation.

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.

Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia.

Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice.

Cardioprotection by postconditioning in conscious rats is limited to coronary occlusions <45 min.

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.

Cardioprotection with alcohol: role of both alcohol and polyphenolic antioxidants.

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation.

Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.

Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites.

CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion.

Cell type-specific localization of human cardiac S1P receptors.

Change in opioid peptide level in the heart and blood plasma during acute myocardial ischaemia complicated by ventricular fibrillation.

Characterisation of the infarct-limiting effect of delayed preconditioning: timecourse and dose-dependency studies in rabbit myocardium.

Characterization of tumor necrosis factor-deficient mice.

Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia.

Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.

Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.

Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.

Coronary microembolization: the role of TNF-alpha in contractile dysfunction.

Crif1 is a novel transcriptional coactivator of STAT3.

Crystal structure of rhodopsin: A G protein-coupled receptor.

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death.

Decreased affinity of K-receptor binding during reperfusion following ischaemic preconditioning in the rat heart.

Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle.

Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism.

Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection.

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors.

Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide.

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival.

Effect of cyclosporine on reperfusion injury in acute myocardial infarction.

Emerging epidemic of cardiovascular disease in developing countries.

Endothelial and antithrombotic actions of HDL.

Endotoxin and ischemic preconditioning: TNF- concentration and myocardial infarct development in rabbits.

Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta.

Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways.

Estimating the burden of disease attributable to high cholesterol in South Africa in

Ethanolamine is a novel STAT-3 dependent cardioprotective agent.

Evidence for a free radical mechanism of reperfusion injury.

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia.

Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts.

Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation.

Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart.

Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol.

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.

Forkhead transcription factors and cardiovascular biology.

Four brief periods of myocardial ischemia cause no cumulative ATP loss or necrosis.

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases.

Free radicals trigger TNF alpha-induced cardioprotection.

Function of mitochondrial Stat3 in cellular respiration.

Functional recovery of diabetic mouse hearts by glutaredoxin-1 gene therapy: role of Akt-FoxO-signaling network.

Gap junction uncoupler heptanol prevents cell-tocell progression of hypercontracture and limits necrosis during myocardial reperfusion.

Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.

Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.

Glycogen synthase kinase3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.

HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects.

Heart Physiology From Cell to Circulation,

Heptahelical receptor signaling: beyond the G protein paradigm.

High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor.

Highdensity lipoproteins protect isolated rat hearts from ischemia-reperfusion injury by reducing cardiac tumor necrosis factor-alpha content and enhancing prostaglandin release.

History of the Circulatory System: discovery of the basics.

The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological postconditioning

https://open.uct.ac.za/bitstream/11427/3467/1/thesis_hsf_2011_somers_s.pdf

The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological postconditioning

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