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Bauer, Mario

Bauer, Tobias

Bieg, Matthias

Borte, Michael

Eils, Roland

Geörg, Christina

Grützmann, Konrad

Gu, Lei

Gu, Zuguang

Herberth, Gunda

Herrmann, Carl

Ishaque, Naveed

Junge, Kristin M.

Lawerenz, Christian

Lehmann, Irina

Mallm, Jan‐Philipp

Mizuguchi, Junichiro

Mücke, Oliver

Plass, Christoph

Polte, Tobias

Rippe, Karsten

Rolle‐Kampczyk, Ulrike

Röder, Stefan

Schanne, Michaela

Schlesner, Matthias

Stunnenberg, Hendrik G.

Takada, Eiko

Thürmann, Loreen

Trump, Saskia

Wang, Qi

Weichenhan, Dieter

Wiemann, Stefan

Winter, Marcus

Molecular Systems Biology

English

PubMed

Bauer, T.

Trump, S.

Ishaque, N.

Thurmann, L.

Gu, L.

Bauer, M.

Bieg, M.

Gu, Z.

Weichenhan, D.

Mallm, J.P.

Roder, S.

Herberth, G.

Takada, E.

Mucke, O.

Winter, M.

Junge, K.M.

Grutzmann, K.

Rolle-Kampczyk, U.

Wang, Q.

Lawerenz, C.

Borte, M.

Polte, T.

Schlesner, M.

Schanne, M.

Wiemann, S.

Georg, C.

Stunnenberg, H.G.

Plass, C.

Rippe, K.

Mizuguchi, J.

Herrmann, C.

Eils, R.

Lehmann, I.

NARCIS 

Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

Radboud Repository

Tobias Bauer

Saskia Trump

Naveed Ishaque

Loreen Thürmann

Lei Gu

Mario Bauer

Matthias Bieg

Zuguang Gu

Dieter Weichenhan

Jan‐Philipp Mallm

Stefan Röder

Gunda Herberth

Eiko Takada

Oliver Mücke

Marcus Winter

Kristin M Junge

Konrad Grützmann

Ulrike Rolle‐Kampczyk

Qi Wang

Christian Lawerenz

Michael Borte

Tobias Polte

Matthias Schlesner

Michaela Schanne

Stefan Wiemann

Christina Geörg

Hendrik G Stunnenberg

Christoph Plass

Karsten Rippe

Junichiro Mizuguchi

Carl Herrmann

Roland Eils

Irina Lehmann

Crossref

Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

Junge, Kristin M

Stunnenberg, Hendrik G

Online-Publikationserver Augsburg

Abstract Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype‐related DNA methylation changes. Differential methylation is enriched in enhancer elements and targets in particular “commuting” enhancers having multiple, regulatory interactions with distal genes. Longitudinal whole‐genome bisulfite sequencing revealed that DNA methylation changes associated with maternal smoking persist over years of life. Particularly in children prenatal environmental exposure leads to chromatin transitions into a hyperactive state. Combined DNA methylation, histone modification, and gene expression analyses indicate that differential methylation in enhancer regions is more often functionally translated than methylation changes in promoters or non‐regulatory elements. Finally, we show that epigenetic deregulation of a commuting enhancer targeting c‐Jun N‐terminal kinase 2 (JNK2) is linked to impaired lung function in early childhood

Directory of Open Access Journals

OPUS Augsburg

Abstract Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype‐related DNA methylation changes. Differential methylation is enriched in enhancer elements and targets in particular “commuting” enhancers having multiple, regulatory interactions with distal genes. Longitudinal whole‐genome bisulfite sequencing revealed that DNA methylation changes associated with maternal smoking persist over years of life. Particularly in children prenatal environmental exposure leads to chromatin transitions into a hyperactive state. Combined DNA methylation, histone modification, and gene expression analyses indicate that differential methylation in enhancer regions is more often functionally translated than methylation changes in promoters or non‐regulatory elements. Finally, we show that epigenetic deregulation of a commuting enhancer targeting c‐Jun N‐terminal kinase 2 (JNK2) is linked to impaired lung function in early childhood.Version of Recor

Harvard University - DASH

Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

Abstract

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