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The impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort
Authors
M. ANDRE
C. ANDRIEU-HALLER
+47 more
Bruno AOUIZERATE
F. BERNA
O. BLANC
E. BOURGUIGNON
L. BOYER
Delphine CAPDEVIELLE
Isabelle CHEREAU
I. CHEREAU-BOUDET
J. CLAUSS-KOBAYASHI
N. COULON
R. DASSING
J.M. DOREY
Caroline DUBERTRET
A. ESSELIN
D. ETCHECOPAR-ETCHART
G. FOND
G. FOND
F. GABAYET
Alexandra GAROSI
Ophelia GODIN
M. JARROIR
D. LACELLE
C. LANÇON
M. LEBOYER
S. LEIGNIER
P.M. LLORCA
J. MALLET
E. METAIRIE
T. MICHEL
David MISDRAHI
C. PASSERIEUX
P. PERI
J. PETRUCCI
B. PIGNON
C. PORTALIER
R. REY
Raphaelle RICHIERI
C. ROMAN
B. SCHORR
Franck SCHURHOFF
Pierre-Louis SUBHARY DE VERVILLE
A. SZOKE
A. SZÖKE
A. TESSIER
M. URBACH
G. WACHICHE
A. ZINETTI-BERTSCHY
Publication date
1 July 2022
Publisher
Doi
Cite
Abstract
Parent history of severe mental illness (PHSMI) may have long-term consequences in adult offspring due to genetic and early environmental factors in preliminary studies. To compare the outcomes associated in subjects with PHSMI to those in patients without PHSMI. The participants with schizophrenia and schizoaffective disorders were recruited in the ongoing FACE-SZ cohort at a national level (10 expert centers) and evaluated with a 1-day-long standardized battery of clinician-rated scales and patient-reported outcomes. PHSMI was defined as history of schizophrenia or bipolar disorders in at least one parent and was included as explanatory variable in multivariate models. Of the 724 included patients, 78 (10.7%) subjects were classified in the PHSMI group. In multivariate analyses, PHSMI patients had a better insight into schizophrenia and the need for treatment and reported more often childhood trauma history compared to patients without PHSMI. More specifically, those with paternal history of SMI reported more severe outcomes (increased childhood physical and emotional abuses, comorbid major depression and psychiatric hospitalizations). PHSMI is associated with increased risk of childhood trauma, major depressive disorder and psychiatric hospitalization and better insight in individuals with schizophrenia. Specific public health prevention programs for parents with SMI should be developed to help protect children from pejorative psychiatric outcomes. PHSMI may also explain in part the association between better insight and increased depression in schizophrenia. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.Sorbonne Universités à Paris pour l'Enseignement et la RechercheFondaMental-Cohorte
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Oskar Bordeaux
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Last time updated on 08/07/2023