'Society of Chemists and Technologists of Macedonia'
Abstract
Flavonoids, widely distributed second metabolites of plants, have a large
number of functions. Nowadays, with more nature-oriented lifestyle, the role in plants
and potential benefits for humans and animals became more and more important.1
3-Hydroxyflavone (3HF) represents the backbone of all flavonols, a
widespread class of flavonoids. Interestingly, this compound is not found naturally in
plants. Regardless, 3HF is commonly applied as a model molecule because it
possesses an excited-state intramolecular proton transfer effect and may serve as a
fluorescent probe in studies of either membranes or intermembrane proteins. It has
also been shown that 3HF inhibits metastasis of human osteosarcoma cells and
reduces tumor growth in vivo.
With aim to find wider application of 3HF, its complexes with metal ions
attract the attention of the researchers. Beside the characterization of zinc complex
with 3HF, we reported the validation of the developed simple and low-cost
spectrophotometric determination of 3-hydroxyflavone based on its zinc complex.
Furthermore, the antioxidant capacities of the synthesized complex and 3HF itself
were tested by the DPPH method, followed by the evaluation of more positive issues
of zinc 3HF complex. The results of the performed study highlighted the suitability
of zinc complex 3HF both for spectrophotometric determination, as well as to explore
future applications of its potent bioactivity
