Morris, Paul G

Nogaret, Alain

Taylor, Joseph

Wells, Stephen

English

The disclosure relates to a computer-implemented method for determining values of biological parameters of a cell, comprising: receiving membrane voltage readings of the cell corresponding to N time points; for a state vector comprising the biological parameters and a plurality of interdependent and time-dependent state variables, including a membrane voltage variable: setting an initial guess of the state vector and parameters; performing an optimization of the state vector by: setting the membrane voltage variable to be equal to a corresponding membrane voltage reading at a number of time points within the N time points; determining an updated value of the state vector by optimizing an objective function that operates on values of the membrane voltage variable and corresponding membrane voltage readings; and repeating the optimization with: the initial estimate of the state vector set to the updated value of the state vector; and the membrane voltage variable set to be equal to a corresponding membrane voltage reading at fewer time points within the N time points

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        Citation for published version:Nogaret, A, Wells, S, Taylor, J & Morris, PG Nov. 09 2023, DETERMINING BIOLOGICAL PARAMETERS OF ACELL, Patent No. WO2023/214156 A1.Publication date:2023Document VersionPublisher's PDF, also known as Version of recordLink to publicationUniversity of BathAlternative formatsIf you require this document in an alternative format, please contact:openaccess@bath.ac.ukGeneral rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Download date: 27. Nov. 2023

DETERMINING BIOLOGICAL PARAMETERS OF A CELL

https://purehost.bath.ac.uk/ws/files/302401658/IP2598_-_Diagnosing_brain_disease_from_electrical_anomalies_of_brain_cells_-_A_Nogaret_-_Published_application.pdf

DETERMINING BIOLOGICAL PARAMETERS OF A CELL

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