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Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction
Authors
A. Ioakeimidou Pagalou, E. Kontogiorgi, M. Antoniadou, E. Kaziani, K. Psaroulis, K. Giamarellos-Bourboulis, E.J. Prekates, A. Antonakos, N. Lassale, P. Gogos, C. on behalf of the Hellenic Sepsis Study Group
Publication date
1 January 2017
Publisher
Abstract
How circulating inflammatory mediators change upon sepsis progression has not been studied. We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Endocan and Ang-2 were the only parameters that were significantly increased among patients who worsened. Any increase of endocan was associated with worsening with odds ratio 16.65 (p < 0.0001). This increase was independently associated with progression into acute respiratory distress syndrome (ARDS) as shown after logistic regression analysis (odds ratio 2.91, p: 0.002). Changes of circulating cytokines do not mediate worsening of the critically ill patients. Instead endocan and Ang2 are increased and this may be interpreted as a key-playing role in the pathogenesis of ARDS and septic shock. Any increase of endocan is a surrogate of worsening of the clinical course. © 2017, Springer-Verlag Berlin Heidelberg
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Last time updated on 10/02/2023