Chai, NC

Dash, PD

Gelaye, B

Gower, BA

Peterlin, BL

Scher, AI

Tietjen, GE

Ward, TN

White, LW

The Journal of Headache and Pain

Harvard University - DASH 

 EHMTI-0184. Ictal adiponectin levels are modulated by painseverity and treatment response in episodic migraineurs  (Article begins on next page)The Harvard community has made this article openly available.Please share how this access benefits you. Your story matters.Citation Chai, NC, B Gelaye, GE Tietjen, PD Dash, BA Gower, LWWhite, TN Ward, AI Scher, and BL Peterlin. 2014. “EHMTI-0184. Ictal adiponectin levels are modulated by pain severity andtreatment response in episodic migraineurs.” The Journal ofHeadache and Pain 15 (Suppl 1): E25. doi:10.1186/1129-2377-15-S1-E25. http://dx.doi.org/10.1186/1129-2377-15-S1-E25.Published Version doi:10.1186/1129-2377-15-S1-E25Accessed February 17, 2015 2:56:05 AM ESTCitable Link http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347445Terms of Use This article was downloaded from Harvard University's DASHrepository, and is made available under the terms and conditionsapplicable to Other Posted Material, as set forth athttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAMEETING ABSTRACT Open AccessEHMTI-0184. Ictal adiponectin levels aremodulated by pain severity and treatmentresponse in episodic migraineursNC Chai1*, B Gelaye2, GE Tietjen3, PD Dash4, BA Gower5, LW White1, TN Ward6, AI Scher7, BL Peterlin1From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014Copenhagen, Denmark. 18-21 September 2014IntroductionAdiponection (ADP) and leptin (LEP) are adipokineswith roles in inflammation.AimTo assess ADP and LEP levels before and after acuteabortive treatment in episodic migraineurs (EM).MethodsPeripheral blood specimens were collected from EMparticipants before and after acute abortive treatmentwith sumatriptan/naproxen sodium versus placebo.ResultsA total of 34 participants (17 responders, 17 non-responders) were included. In all participants, for every1 point increase in the HMW:T-ADP ratio, pain severityincreased by 4.11 (CI: 0.44, 7.77; p = 0.028). In responders(n = 17), crude T-ADP levels were reduced at 30 min(11.49 ± 3.7; p = 0.001), 60 min (11.54 ± 3.2; p = 0.001)and 120 min (11.39 ± 3.7; p = 0.001) after treatment ascompared to onset (12.47 ± 3.6). In non-responders (n =17), crude T-ADP levels were unchanged after treatment.After adjustments, T-ADP levels remained decreased 30-120 min after treatment in responders; additionally,HMW-ADP, and the HMW:T-ADP ratio were decreasedand LMW-ADP and the LMW:T-ADP ratio (coeff 0.04;CI: 0.01, 0.07; p = 0.043) were increased 120 min aftertreatment in responders. In non-responders, the adjustedLMW-ADP (coef -0.45; CI: -0.77, -0.14; p = 0.005) and theLMW:T-ADP ratio (coef -0.04; CI: -0.07, -0.01; p = 0.018)were decreased at 60 min as well as at 120 min aftertreatment. Unadjusted and adjusted LEP levels were notmodulated by changes in pain severity or treatmentresponse.ConclusionAdiponectin, but not leptin, is associated with painseverity and is modulated by treatment response in epi-sodic migraineurs.Conflict of interest.Authors’ details1Neurology, Johns Hopkins University School of Medicine, Baltimore, USA.2Epidemiology, Harvard School of Public Health, Boston, USA.3Neurology,University of Toledo, Toledo, USA.4Neurology, Johns Hopkins CommunityPhysicians, Baltimore, USA.5Department of Nutrition Sciences, University ofAlabama at Birmingham, Birmingham, USA.6Neurology, DartmouthHitchcock Medical Center, Lebanon, USA.7Preventive Medicine andBiometrics, Uniformed Services University, Bethesda, USA.Published: 18 September 2014doi:10.1186/1129-2377-15-S1-E25Cite this article as: Chai et al.: EHMTI-0184. Ictal adiponectin levels aremodulated by pain severity and treatment response in episodicmigraineurs. The Journal of Headache and Pain 2014 15(Suppl 1):E25.1Neurology, Johns Hopkins University School of Medicine, Baltimore, USAFull list of author information is available at the end of the articleChai et al. The Journal of Headache and Pain 2014, 15(Suppl 1):E25http://www.thejournalofheadacheandpain.com/content/15/S1/E25© 2014 Chai et al; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons AttributionLicense (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium,provided the original work is properly cited.

EHMTI-0184. Ictal adiponectin levels are modulated by pain severity and treatment response in episodic migraineurs

EHMTI-0184. Ictal adiponectin levels are modulated by pain severity and treatment response in episodic migraineurs

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