Acute Toxicity Sudy of Eladi Quatha: A Compound Ayurvedic Formulation

Abstract

In the modern era, the Indian Ayurvedic system of Medicine is believed to treat diseases from the root cause. The ayurvedic system claims to have many indigenous plants and herbal preparations, which provide therapeutic benefit in the treatment of kidney diseases. Aim – To study the benefits of herbal preparation Eladi quatha for kidney disease Urothalisis. Method - This study was undertaken to explore the effects of Eladi quatha in animals to treat kidney stone diseases. However, no safety profile for this formulation has been reported to date; thus, in this study, freshly prepared Eladi quatha was evaluated for acute toxicity. Acute toxicity test was evaluated as per OECD 423 guidelines with 5000 mg/kg as a limit test in Wistar strain Albino rats. Test formulations were administered to overnight fasted animals and parameters like body weight, behavioral changes, and mortality were assessed for 14 days. Hematological and biochemical parameters were assessed on the 14th day after administration. Result - No significant changes were noted in terms of behavioral changes, mortality, and body weight. The samples did not affect any of the hematological parameters. However, an increase in blood urea level was observed. Conclusion- This study concludes that freshly prepared Eladi quatha is relatively safe up to the dose of 5000 mg/kg. However, further chronic toxicity evaluation is necessary to establish its safety profile on chronic administration

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