The study aim was to compare the effects of a 7-week plyometric, strength and change of direction (COD) training program on basketball-specific performance measures in high-school players. Forty male players were randomly assigned to one of the four groups: plyometric (PG, n = 10), strength (SG, n = 10), COD (CODG, n = 10), and control group training (CG, n = 10). Two training sessions were performed at weekly intervals before basketball training. Performance of the counter movement jump (CMJ), Abalakov jump (ABKJ), 10 m zig-zag sprint, 20 m in line sprint (measurements at 10 and 20 m), and sit and reach flexibility test (SRFT) was assessed before and after the intervention. A 4 (group) x 2 (time) repeated measures analysis of variances (ANOVA) was conducted for each variable. Bonferroni post-hoc tests were used when the interaction was significant. Significant (all p < 0.05) time x group interaction was noted for SRFT, CMJ, ABK, sprint, and zig-zag 10 m, in favor of the experimental groups compared to the control group. However, improvements in physical fitness were similar between the three experimental groups. In conclusion, 7 weeks of specific plyometric, strength and COD training produced similar medium to large improvements in physical fitness of high-school basketball players