Axmacher, Nikolai

Bellaali, Youssef

Bierbrauer, Anne

Colmant, Lise

Hanseeuw, Bernard

Kunz, Lukas

Lefevre, Philippe

Sleegers, Kristel

Van Dongen, Jasper

Abstract: Path integration is a spatial navigation ability that requires the integration of information derived from self motion cues and stable landmarks, when available, to return to a previous location. Path integration declines with age and Alzheimer's disease (AD). Here, we sought to separate the effects of age and AD risk on path integration, with and without a landmark. Overall, 279 people participated, aged between 18 and 80 years old. Advanced age impaired the appropriate use of a landmark. Older participants furthermore remembered the location of the goal relative to their starting location and reproduced this initial view without considering that they had moved in the environment. This lack of adaptative behavior was not associated with AD risk. In contrast, participants at genetic risk of AD (apolipoprotein E epsilon 4 carriers) exhibited a pure path integration deficit, corresponding to difficulty in performing path integration in the absence of a landmark. Our results show that advanced-age impacts landmark-supported path integration, and that this age effect is dissociable from the effects of AD risk impacting pure path integration.(c) 2023 Elsevier Inc. All rights reserved

Institutional Repository Universiteit Antwerpen

Dissociating effects of aging and genetic risk of sporadic Alzheimer's disease on path integration

Dissociating effects of aging and genetic risk of sporadic Alzheimer's disease on path integration

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Institutional Repository Universiteit Antwerpen