Hinow, Peter

English

ISU ReD: Research and eData

Presentation for the Symposium on BEER November 2023A mathematical model of the disruption of glucosehomeostasis in cancer patientsPeter Hinow1*, Noah Salentine1, Jonathan Doria1, Chinh Nguyen1, Gabriella Pinter1,Shizhen Emily Wang21Department of Mathematical Sciences, University of Wisconsin - Milwaukee, Milwaukee, WI 53201, USA2Department of Pathology, University of California San Diego, La Jolla, CA 92093, USAhinow@uwm.eduWe investigate the disruption of the glucose homeostasis at the whole-body level by the presence of cancerdisease. Of particular interest are the potentially different responses of patients with or without hyper-glycemia (including Diabetes Mellitus) to the cancer challenge, and how tumor growth, in turn, responds tohyperglycemia and its medical management. We propose a mathematical model that describes the competi-tion between cancer cells and glucose-dependent healthy cells for a shared glucose resource. We also includethe metabolic reprogramming of healthy cells by cancer-cell-initiated mechanism to reflect the interplay be-tween the two cell populations. We parametrize this model and carry out numerical simulations of variousscenarios, with growth of tumor mass and loss of healthy body mass as endpoints. We report sets of cancercharacteristics that show plausible disease histories. We investigate parameters that change cancer cells’aggressiveness, and we exhibit differing responses in diabetic and non-diabetic, in the absence or presenceof glycemic control. Our model predictions are in line with observations of weight loss in cancer patientsand the increased growth (or earlier onset) of tumor in diabetic individuals. The model will also aid futurestudies on countermeasures such as the reduction of circulating glucose in cancer patients.

A mathematical model of the disruption of glucose homeostasis in cancer patients

https://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1670&context=beer

A mathematical model of the disruption of glucose homeostasis in cancer patients

Abstract

Similar works

Full text

Available Versions

ISU ReD: Research and eData