With the recent report of a pregnancy and delivery after
autotransplantation of cryopreserved-thawed ovarian cortical strips,
preservation of the reproductive potential resurfaced. There is a
growing academic and public interest in exploring the available
strategies for fertility preservation in patients at risk. This is due
to the increasing incidence of cancer during the reproductive age. The
overall survival and cure rates of reproductive age cancers are
improving due to improvements in cancer therapy. Reproductive
derangement is one of the major consequences of cytotoxic chemotherapy
and radiotherapy. GnRh analogues concomitant therapy, laparoscopic
ovarian transposition, oocyte cryopreservation, embryo cryopreservation
and transplantation of cryopreserved-thawed ovarian tissue, are all
strategies for fertility preservation in patients at risk. However, no
evidence-based strategy is available yet. This article discusses the
mechanisms of reproductive failure after gonadotoxic therapy and the
currently available fertility preservation strategies
