ABSTRACT: Biochemical recurrence of prostate cancer, detected by a rising PSA, may reflect intraprostatic or extraprostatic recurrence. 18F-Fluciclovine (Axumin), a synthetic amino acid substrate in tumor metabolism, has frequently been used for to localize recurrent prostate cancers. We present a 71-year-old man with biochemical recurrence of prostate cancer but no convincing imaging findings on 18F-fluciclovine PET/CT. Of note, however, was an incidental uptake within the anterior mediastinum, which was found on biopsy to be a type AB thymoma. With this, we stress that awareness of false-positive uptake patterns is crucial for accurate diagnosis of recurrent prostate cancer
