https://digitalcommons.unmc.edu/surp2023/1011/thumbnail.jp

Cheek, Hailey

Lyden, Elizabeth

Peeples, Eric

English

University of Nebraska Medical Center Research: DigitalCommons@UNMC

University of Nebraska Medical Center DigitalCommons@UNMC Posters: 2023 Summer Undergraduate Research Program Summer Undergraduate Research Program Summer 2023 Identifying Risk Factors for Significant Hyponatremia during Vasopressin Administration in Neonates Hailey Cheek University of Nebraska Medical Center Elizabeth Lyden University of Nebraska Medical Center Eric Peeples University of Nebraska Medical Center Tell us how you used this information in this short survey. Follow this and additional works at: https://digitalcommons.unmc.edu/surp2023 Recommended Citation Cheek, Hailey; Lyden, Elizabeth; and Peeples, Eric, "Identifying Risk Factors for Significant Hyponatremia during Vasopressin Administration in Neonates" (2023). Posters: 2023 Summer Undergraduate Research Program. 12. https://digitalcommons.unmc.edu/surp2023/12 This Poster is brought to you for free and open access by the Summer Undergraduate Research Program at DigitalCommons@UNMC. It has been accepted for inclusion in Posters: 2023 Summer Undergraduate Research Program by an authorized administrator of DigitalCommons@UNMC. For more information, please contact digitalcommons@unmc.edu. Summer Undergraduate Research Program2023BACKGROUND: Vasopressin could be an effective medication to raise blood pressure in neonates, but limited literature exists regarding safety in this population. Significant hyponatremia has been observed with the use of vasopressin locally, which warrants further investigation.METHODS1. Approval obtained from UNMC/CHMC IRB2. Included all neonates who received medications to raise blood pressure admitted 1/1/13 - 4/1/233. Collected serum electrolytes and fluid intake/output for first 7 days after starting vasopressin4. Significant hyponatremia defined as <130 mEq/L at any point in the first 7 daysRESULTS• 47 infants met inclusion; 22 had significant hyponatremia• No significant difference in demographics between hyponatremic and normal sodium groupsHailey Cheek; Elizabeth Lyden; Eric PeeplesUNMC; Child Health Research Institute; Children’s Hospital and Medical CenterIdentifying risk factors for significant hyponatremia during vasopressin administration in neonatesIn newborns receiving vasopressin for blood pressure support, hyponatremia is associated with higher fluid intake and higher creatinine levels• Hyponatremia was associated with higher initial creatinine and total fluids and longer duration of vasopressin• Groups did not differ by gestational age, birth weight, initial dose, or peak dose of vasopressin• These data could aid in the development of clinical guidelines to help direct the safe and effective administration of vasopressin for blood pressure support in neonatesCONCLUSIONSFigure 2. Electrolytes, total fluids, and urine output for first week after vasopressin initiation. p values listed are from mixed linear model for difference by sodium group (“group”), days, or both.Figure 1. No differences in starting dose, peak dose, or the day of life (DOL) vasopressin was initiated, but hyponatremia group had longer vasopressin treatment duration.Table 1. Demographics and outcomes, stratified by serum sodium group. Categorical: n (%), continuous: median (min, max). *3 missing in Na ≥ 130 mEq/L group

Identifying Risk Factors for Significant Hyponatremia during Vasopressin Administration in Neonates

https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1011&context=surp2023

Identifying Risk Factors for Significant Hyponatremia during Vasopressin Administration in Neonates

Abstract

Similar works

Full text

Available Versions

University of Nebraska Medical Center Research: DigitalCommons@UNMC