Stem Cells in Cervical Cancer: An Overview

Abstract

Cervical cancer has emerged as the leading cause of women's cancer-related deaths despite screening and vaccination programs. Surgery and chemotherapy help patients with cervical cancer live longer, but they do not provide a permanent cure. Radical surgery is the only option in the advanced stage of cervical cancer, which also affects patients' ability to conceive. Sometimes it also causes the disease to return. As a result, new therapeutics must be developed immediately. According to the CSC hypothesis, a tumor has a hierarchical cellular structure with a small subset of cells called cancer stem cells that induce tumorigenesis. The CSCs' tumor-initiating capacity has been the subject of numerous studies. These CSCs are crucial in tumor metastasis, relapse, and radiotherapy resistance. Because they play a role at the beginning of the spread of the tumor, they are thought to improve outcomes. The most well-known gynecological danger is cervical carcinoma, which shows a high malignant growth death rate in females. As a result, research into cervical cancer has increasingly turned to stem cells from the disease. In this review, we have summarized CSCs and CCSCs as emerging key players in cervical cancer early diagnosis and as a therapeutic target in this cancer. Keywords: Cancer, Cervical Cancer, Cancer Stem Cell, Cervical Cancer Stem Cell, Human Papilloma Viru