Classification methods are a popular method applied in many various fields of science. To represent the effect of predictor factors on categorical response variables, different machine learning classification algorithms are used, namely logistic regression, neural network (NN), random forest, support vector machine (SVM), and bayesian model averaging (BMA). Every classifier has its unique characteristic, performing well in certain datasets but not in others. Hence, it is always a quest to find the best classifier to use for a certain dataset. Economic growth, most commonly using a gross regional domestic product, is experiencing a recession or acceleration, especially before and during the COVID-19 pandemic. This research proposed a comparison of classification methods using regional GDP data for 2019-2020, before and during the COVID-19 pandemic, by predictor variables; percentage of workers, foreign direct investment (PMA), regional revenue (PAD), general allocation fund (DAU), revenue sharing fund (DBH), and the dummy of COVID-19. The results are that all selected machine learning models can classify the regional GDP growth perfectly for the training data, but, NN model outperforms the other methods with an accuracy of 100% in training and testing data. COVID-19 and the PMA are the most significant variables predicting regional GDP growth for all models. Further research relating to interpretable machine learning, such as feature interaction, global surrogate, and Shapley values, is also necessary to predict regional GDP growth using machine learning methods
