Objective: to explore whether the application of nursing risk management in physical examination center has positive significance; Method: 50 patients who received medical examination from December 1st to 31st, 2019 were randomly divided into two groups according to the number of the medical examination card, 25 patients in Group A were given routine nursing management, which will be referred as the control group hereafter while group B with 25 people will have the nursing risk management, which will be referred as the observation group. After all the physical examination items ended, statistical physical examination results and the degree of satisfaction of the physical examination will be recorded. Results: Errors of the observation group in the physical examination process were significantly less than that of the control group (P<0.05) and the degree of satisfaction of physical examinees in the observation group was higher than that in the control group(P<0.05). Conclusion: The use of nursing risk management in medical examination center can improve the degree of satisfaction of medical examiners and reduce the occurrence of accidents and disputes