Objective To summarize the perioperative nursing experience of comprehensive nursing intervention in 53 patients who underwent radical thyroidectomy under complete endoscopy in our department. Methods A retrospective analysis was made of the perioperative nursing points of 53 patients with total endoscopic radical thyroidectomy. Including preoperative psychological care, neck back position training, postoperative observation of changes in the condition, neck and shoulder function exercise, local cold compress, keep drainage tube unobstructed, complications prevention, observation and nursing. Results All the 53 patients were cured and discharged without hyperthyroidism crisis and parathyroid injury. Conclusion Perioperative implementation of comprehensive nursing intervention measures, close observation of the condition changes, patient guidance, seriously answer the doubts of patients so that patients actively cooperate with nursing treatment, can effectively reduce complications, reduce patient pain, improve patient satisfaction