Barbero, N.

Butnarasu, C.

Chinigò, G.

Fiorio Pla, A.

Moràn Plata, M. J.

Pontremoli, C.

Sansone, E.

Visentin, S.

English

Institutional Research Information System University of Turin

18th International Conference on Nanosciences & Nanotechnologies (NN21)6-9 July 2021, Thessaloniki, GreeceCarbon nanodots as nanocarrier for Squaraines: an in vitro evaluation of their Photodynamic activityC. Butnarasu1, C. Pontremoli2, M.J. Moràn Plata2, E. Sansone3, G. Chinigò3, A. Fiorio Pla3, N. Barbero2, and S. Visentin11 Department of Molecular Biotechnology and Health Sciences, University of Torino, via Quarello 15a, Torino, Italy2 Department of Chemistry, NIS Interdepartmental and INSTM Reference Centre, University of Torino, via Giuria 7, Torino, Italy3 Department of Life Sciences and Systems Biology, University of Torino, via Accademia Albertina 13, Torino, ItalyAbstract: Over the recent years, extensive efforts have been devoted to the development of near-infrared (NIR) dyes for biological applications, especially for photodynamic therapy (PDT). Polymethine dyes can be considered as innovative photosensitizers (PS) due to the easy and low-cost synthesis along with remarkable absorption property in the far-red NIR region, perfectly matching the biological tissues’ transparency window (600-900 nm). In particular, NIR polymethine cyanines (CY) and squaraines (SQ) are well suited for this purpose and have been extensively studied for these applications, thanks to their high molar absorption coefficients, remarkable brightness, fluorescence and photostability, especially in organic media. Despite their excellent photochemical properties, their chemical instability and self-aggregation when in contact with biological media still limit their effective clinical application. To overcome these drawbacks, the development of a nanocarrier in which the dye is incorporated into biocompatible nanoparticles could be considered a promising approach to prevent the formation of dye aggregates and thus increase its solubility in aqueous environment. Carbon nanodots (C-dots) are a new class of carbon-based nanomaterials with exclusive features, such as unique optical properties, aqueous solubility, excellent biocompatibility and low toxicity. For these reasons, they have been studied and applied in a wide range of biomedical fields, including drug delivery. The present contribution deals with the preparation of C-dots complexes with a SQ dye active in in vitro PDT, to promote its use in physiological conditions. Preliminary results showed that C-dots-dye complex exhibit good optical properties, good biocompatibility and in vitro photodynamic activity.

Carbon nanodots as nanocarrier for Squaraines: an in vitro evaluation of their Photodynamic activity

https://iris.unito.it/bitstream/2318/1801747/1/NN21_ABSTRACT_PONTREMOLI.doc

Carbon nanodots as nanocarrier for Squaraines: an in vitro evaluation of their Photodynamic activity

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