Bono, R.

Squillacioti, G.

English

Institutional Research Information System University of Turin

C25 EARLY LIFE EXPOSURES AS DETERMINANTS OF RESPIRATORY DISEASE / RAPiD: Rapid Abstract Poster Discussion SessionGreater Risk of Asthma and Allergic Rhinitis, But Not Eczema, Associated with Living Closeto Green Space in European Children. The Heals ProjectI. Annesi-Maesano1, C. N. Maesano1, S. Baldacci2, R. Bono3, S. Brescianini4, C. D'Ippolito4, W. Hanke5, M. Horvat6, H.Liedes7, S. Maio2, P. Marchetti8, A. Marcon8, E. Medda4, M. Molinier7, S. Panunzi8, J. Pärkkä7, K. Pola&#324;ska5, J.Prud'homme9, P. Ricci10, C. E. Sabel11, J. Snoj Tratnik6, G. Squillacioti3, M. A. Stazi4, E. Parmes7, G. Pesce9; 1Epidemiologyof Allergic and Respiratory Diseases, INSERM, Paris, France, 2Pulmonary Environmental Epidemiology Unit, CNR Institute ofClinical Physiology, Pisa, Italy, 3Department of Public Health and Paediatrics, University of Turin, Turin, Italy, 4Centre forBehavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy, 5Department of EnvironmentalEpidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland, 6Department of Environmental Sciences, Jo&#382;efStefan Institute, Ljubljana, Slovenia, 7VTT Technical Research Centre of Finland Ltd, Espoo, Finland, 8Unit of Epidemiologyand Medical Statistics, University of Verona, Verona, Italy, 9Epidemiology of Allergic and Respiratory Diseases, SorbonneUniversité, Paris, France, 10Unità Operativa Complessa Osservatorio Epidemiologico, Agenzia Tutela Salute della ValPadana, Mantova, Italy, 11Department of Environmental Science, BERTHA, The Danish Big Data centre for Environment andHealth, Aarhus, Denmark.Corresponding author's email: isabella.annesi-maesano@inserm.frRationale: While recent research has shown an overall beneficial impact of surrounding green space on general health, thereare contradictory and non-conclusive results regarding the relation between residential green space and the development ofrespiratory and allergic diseases. Aims: This study aims to evaluate the associations of residential land cover (green, grey, andagricultural space) with childhood allergic and respiratory diseases. A secondary analysis was also conducted to investigatethe effects of proximity to different types of forests (deciduous, coniferous, and mixed) and health outcomes. Methods: Datafrom over eight-thousand children, aged 3-14 years, were obtained from nine European population-based studies participatingin the HEALS consortium (“Health and Environment-wide Associations based on Large population Surveys”, www.heals-eu.eu). Information on lifetime occurrence of wheezing, asthma, rhinitis and eczema, family lifestyle and socio-demographiccharacteristics were collected through parental-administered questionnaires. Land-cover within a 500 m buffer from children’shome addresses was computed using data from the Coordination of Information on the Environment (CORINE) inventory.Logistic regression models were fitted to estimate the associations of the health outcomes with CORINE land-cover featureswithin each study, adjusting for sex, age, body mass index, maternal education, parental smoking, and parental history ofallergy. The pooled effects across studies were estimated using meta-analyses. Results: The results from the meta-analysesshowed that a 10% increase in green space coverage was significantly associated with an increased risk of wheezing (oddsratio [95% confidence interval]: 1.059 [1.008-1.114]), asthma (1.092 [1.011-1.178]) and rhinitis (1.081 [1.008-1.160]), but noteczema (1.009 [0.957-1.064]). The estimates did not depend on gender and age and were confirmed using different buffer radiiand after controlling for outdoor residential NO2 and PM10 levels. A lower risk of respiratory symptoms in subjects exposed toresidential agricultural space was also observed, but did not reach statistical significance. Grey (urban) space was notassociated with any of the considered outcomes. In secondary analyses, living close to forests of conifers, but not other foresttypes, was significantly associated with greater odds of wheezing (3.95 [2.08-7.49]), asthma (2.54 [1.10-5.82]) and rhinitis (3.39[1.83-6.30]). Conclusions: Our findings provide further evidence that exposure to green space is associated with increased riskof wheezing, asthma, and allergic rhinitis in childhood. Moreover, our results suggest that living in proximity to coniferousforests may influence the onset of respiratory diseases probably due to the exposures to pollen, moulds and biogenic volatileorganic compounds. This abstract is funded by: European Union's 7th Framework Programme for Research #603946Am J Respir Crit Care Med 2020;201:A4613Internet address: www.atsjournals.org  Online Abstracts Issue 

Greater Risk of Asthma and Allergic Rhinitis, But Not Eczema, Associated with Living Close to Green Space in European Children. The Heals Project

https://iris.unito.it/bitstream/2318/1840192/1/ajrccm-conference.2020.201.1_meetingabstracts.a4613.pdf

Greater Risk of Asthma and Allergic Rhinitis, But Not Eczema, Associated with Living Close to Green Space in European Children. The Heals Project

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