IMPACT OF ADHERENCE TO A HIGH-PROTEIN DIET IN CLINICAL TRIALS: METHODOLOGICAL CONSIDERATIONS IN ELDERLY GROUPS

Abstract

Background/objectives: several randomized clinical trials (ECRs) showed no consistent responses of dietary treatments to clinical outcomes. It is speculated that it is due to low adherence to dietary guidelines. It is aimed at identifying the proportion of samples that joined the protein-rich diet and the effect of adhesion in different health outcomes in postmenopausal women. Methods: it was performed in 52 women participating in a physical activity program, all with a protein -rich diet for 12 weeks, with nutritional follow -up. The prescribed diet contained 1.3-1.6g/kg/day of protein, minimum intake of 1.2g/kg/day was considered adhesion. Eight 24 -hour memories were performed by participant. Adhesion was also analyzed in the urinary excretion of urea and uric acid. The effect was analyzed in anthropometric and cardiometabolic parameters. The analysis of unilateral variance was used. Results: Despite significant increase in protein intake, only 38.5% reached the desired intake. A significant increase in urea was observed only in the high protein group (1.16 x 2.57, p <0.05). Women who joined the protein -rich diet (n = 20) had significant clinical results in body mass index, plasma cholesterol and urea levels, both with p <0.05. Conclusion: postmenopausal women showed low adherence to the protein-rich diet, according to metabolite analysis and statistics by unilateral variance analysis. Thus, in ECRs it is essential to consider nutrient intake and not just prescription, also highlighting the importance of food and nutritional education actions to stimulate adherence to the proposed

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